Morgan D J, Horowitz J D, Louis W J
Victorian College of Pharmacy, Melbourne, Australia.
J Pharm Sci. 1989 May;78(5):384-8. doi: 10.1002/jps.2600780508.
Using peripheral blood concentration and myocardial content data (from coronary sinus catheterization and serial determination of transmyocardial drug concentration gradients) from a previous clinical study of the antiarrhythmic drugs lidocaine and mexiletine, we tested the hypothesis that two prospectively defined models of myocardial drug disposition could be used to predict myocardial drug content, in the first 30 min following bolus iv injection, from peripheral blood concentrations alone. Compartmental analysis of peripheral blood concentration data from prolonged blood sampling (three-compartment model) and from the first 30 min after drug injection (two-compartment model) was used to calculate drug content, during the first 30 min, in the second compartment of each of the models. The time course of calculated compartmental content was similar to that of the measured myocardial content in 16 of the 18 patients studied, although there were some differences in the time of peak content. This relatively noninvasive method may therefore be useful in predicting the time course of myocardial drug content after acute iv drug administration.
利用先前关于抗心律失常药物利多卡因和美西律的临床研究中的外周血浓度和心肌含量数据（来自冠状窦插管和跨心肌药物浓度梯度的系列测定），我们检验了这样一个假设：在静脉推注后的最初30分钟内，仅根据外周血浓度，两种预先定义的心肌药物处置模型可用于预测心肌药物含量。对长时间采血（三室模型）和药物注射后最初30分钟（二室模型）的外周血浓度数据进行房室分析，以计算每个模型第二个房室在最初30分钟内的药物含量。在所研究的18例患者中，有16例计算得到的房室含量的时间进程与测量得到的心肌含量相似，尽管峰值含量出现的时间存在一些差异。因此，这种相对非侵入性的方法可能有助于预测急性静脉给药后心肌药物含量的时间进程。
