Snyder D W
J La State Med Soc. 1989 May;141(5):21-5.
Tocainide, mexiletine and moricizine belong to class IB of Vaughan Williams system of classification of antiarrhythmic drugs. Mexiletine and tocainide have little or no effect on Phase 0 of action potential and conduction velocity. Their principal effect is to shorten the action potential duration. Moricizine does not fit precisely into the Vaughan Williams system of classification, but has been categorized with class IB agents because in vitro its effects are similar to those of lidocaine. In this article, the pharmacokinetics, electrophysiologic effects, and clinical uses of these three agents are reviewed.
妥卡尼、美西律和莫雷西嗪属于抗心律失常药物 Vaughan Williams 分类系统的 IB 类。美西律和妥卡尼对动作电位 0 期和传导速度几乎没有影响。它们的主要作用是缩短动作电位持续时间。莫雷西嗪并不完全符合 Vaughan Williams 分类系统，但已被归类为 IB 类药物，因为在体外其作用与利多卡因相似。本文对这三种药物的药代动力学、电生理作用及临床应用进行综述。
