肾癌与职业性三氯乙烯暴露之间的关联。
Association Between Kidney Cancer and Occupational Exposure to Trichloroethylene.
作者信息
Buhagen Morten, Grønskag Anna, Ragde Siri Fenstad, Hilt Bjørn
机构信息
Department of Occupational Medicine, St. Olavs University Hospital in Trondheim (Mr Buhagen, Dr Grønskag, Ms Ragde, Dr Hilt); and Department of General Practice and Community Medicine, Faculty of Medicine, NTNU, Norwegian University of Science and Technology, Trondheim, Norway (Mr Buhagen, Drs Grønskag, Hilt).
出版信息
J Occup Environ Med. 2016 Sep;58(9):957-9. doi: 10.1097/JOM.0000000000000838.
OBJECTIVE
This study investigates the association between occupational exposure to trichloroethylene (TCE) and kidney cancer, as this correlation has been questioned.
METHODS
The incidence of cancers was studied in a dynamic cohort of 997 male workers who for many years had been occupationally exposed to TCE.
RESULTS
During a 50-year observation period, 13 cases of kidney cancer were observed (7.5 expected) with a standardized incidence ratio of 1.7 and a 95% confidence interval of 1.0 to 3.0. Four other cases, not included in the SIR analysis, were also observed. Long-term TCE exposure was positively confirmed for 14 of the 17 incident cases. There is reason to assume that the remaining cases also had been exposed to TCE.
CONCLUSIONS
The present study supports the view that TCE is a kidney carcinogen.
目的
本研究调查职业性接触三氯乙烯（TCE）与肾癌之间的关联，因为这种相关性一直受到质疑。
方法
对997名长期职业性接触TCE的男性工人动态队列中的癌症发病率进行了研究。
结果
在50年的观察期内，观察到13例肾癌（预期7.5例），标准化发病率为1.7，95%置信区间为1.0至3.0。还观察到另外4例未纳入标准化发病率分析的病例。在17例发病病例中，有14例被明确证实长期接触TCE。有理由认为其余病例也接触过TCE。
结论
本研究支持TCE是一种肾致癌物的观点。
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