Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA.
Dartmouth College, Hanover, NH 03755, USA.
Int J Environ Res Public Health. 2022 Jan 6;19(2):618. doi: 10.3390/ijerph19020618.
Trichloroethylene (TCE) is a well-documented kidney carcinogen based on a substantial body of evidence including mechanistic and animal studies, as well as reports from occupational settings. However, the cancer risks for those in residential exposures such as TCE contamination in groundwater are much less clear. The objective of this study was to perform a detailed spatio-temporal analysis of estimated residential TCE exposure in New Hampshire, US. We identified kidney cancer cases ( = 292) and age-, gender-matched controls ( = 448) from the Dartmouth-Hitchcock Health System and queried a commercial financial database for address histories. We used publically available data on TCE levels in groundwater measured at contaminated sites in New Hampshire and then modeled the spatial dispersion and temporal decay. We overlaid geospatial residential locations of cases and controls with yearly maps of estimated TCE levels to estimate median exposures over the 5, 10, and 15-year epochs before diagnosis. The 50th-75th percentile of estimated residential exposure over a 15-year period was associated with increased kidney cancer risk (adjusted Odds Ratio (OR) 1.78 95% CI 1.05-3.03), compared to <50th percentile. This finding supports the need for groundwater monitoring of TCE contaminated sites to identify potential public health risks.
三氯乙烯（TCE）是一种经过充分证实的肾脏致癌物，其证据包括机制研究、动物研究以及职业环境报告。然而，对于那些居住在接触环境（如地下水 TCE 污染）中的人来说，其癌症风险则不太明确。本研究的目的是对美国新罕布什尔州的居民 TCE 暴露进行详细的时空分析。我们从达特茅斯-希区柯克医疗系统中确定了肾脏癌病例（n=292）和年龄、性别匹配的对照组（n=448），并查询了商业金融数据库以获取地址记录。我们使用了新罕布什尔州受污染地点测量的地下水 TCE 水平的公开可用数据，然后对空间分布和时间衰减进行建模。我们将病例和对照组的地理位置与每年估计的 TCE 水平的地图重叠，以估计诊断前 5、10 和 15 年期间的中位数暴露量。与<50 百分位相比，在 15 年期间，估计的居住暴露量的第 50-75 百分位数与肾脏癌风险增加相关（调整后的优势比（OR）1.78，95%CI 1.05-3.03）。这一发现支持对 TCE 污染地点进行地下水监测，以识别潜在的公共卫生风险。
