Levy Rebecca A, Kumarapeli Asangi R, Spencer Horace J, Quick Charles M
University of Arkansas for Medical Sciences, Department of Pathology, Slot 517, 4301 West Markham St. Little Rock, AR 72205, United States.
Pathol Res Pract. 2016 Sep;212(9):800-3. doi: 10.1016/j.prp.2016.06.010. Epub 2016 Jun 25.
The aim of this study was to examine a series of clinically identified cervical polyps and determine the incidence of significant histologic and concurrent cytologic findings.
Consecutive cervical polyps from January 2000 through September 2012 were retrieved from the hospital laboratory information system. Histologic evaluation of these polyps was performed, followed by a chart review of clinical findings and correlation with the immediately prior or concurrently collected cervical Papanicolaou (Pap) test results, when available.
A total of 369 cervical polyps were identified and reviewed. The patient ages ranged from 18 to 87 years (mean 46.5years). Eight polyps demonstrated squamous dysplasia (6 Cervical Intraepithelial Neoplasia/CIN I, and 2 CIN II/III), while 6 had malignant or atypical/potentially malignant features (2 adenosarcoma, 2 atypical polyps concerning for Mullerian adenosarcoma, 1 endometrioid endometrial adenocarcinoma and 1 adenocarcinoma in-situ). An increased incidence of atypical squamous cells of undetermined significance (ASCUS) and atypical glandular cells not otherwise specified (AGC NOS) Pap diagnoses (12.7% and 6.1%, respectively) was found in women with benign polyps on biopsy.
We demonstrated a higher rate of clinically significant histologic findings in cervical polyps (14 of 369 cases, 3.7%) compared to previously reported studies. The increase in ASCUS and AGC Pap results was most likely related to reactive and inflammatory changes present in benign polyps. Our results suggest that removal of all cervical polyps with subsequent histologic review is warranted.
本研究旨在检查一系列临床确诊的宫颈息肉，并确定显著组织学和同时存在的细胞学发现的发生率。
从医院实验室信息系统中检索2000年1月至2012年9月连续的宫颈息肉。对这些息肉进行组织学评估，随后对临床发现进行病历回顾，并在可行时将其与紧接之前或同时收集的宫颈巴氏试验结果进行关联。
共鉴定并审查了369例宫颈息肉。患者年龄在18至87岁之间（平均46.5岁）。8例息肉显示鳞状上皮发育异常（6例宫颈上皮内瘤变/CIN I，2例CIN II/III），而6例具有恶性或非典型/潜在恶性特征（2例腺肉瘤，2例可疑穆勒管腺肉瘤的非典型息肉，1例子宫内膜样腺癌和1例原位腺癌）。在活检为良性息肉的女性中，未明确意义的非典型鳞状细胞（ASCUS）和未另行指定的非典型腺细胞（AGC NOS）巴氏诊断的发生率增加（分别为12.7%和6.1%）。
与先前报道的研究相比，我们发现宫颈息肉中具有临床意义的组织学发现率更高（369例中有14例，3.7%）。ASCUS和AGC巴氏结果的增加最可能与良性息肉中存在的反应性和炎症性改变有关。我们的结果表明，切除所有宫颈息肉并随后进行组织学检查是必要的。
