Jones Samuel H, Iannone Andrew F, Patel Kunal S, Anchouche Khalil, Raza Shaan M, Anand Vijay K, Schwartz Theodore H
Departments of *Neurological Surgery,‡Otolaryngology, and§Neuroscience, Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York.
Neurosurgery. 2016 Nov;79(5):736-745. doi: 10.1227/NEU.0000000000001360.
Midline ventral skull base meningiomas may be amenable to an endonasal endoscopic approach, which has theoretical advantages and may help preserve quality of life (QOL) when compared with transcranial approaches.
To investigate the effect of age on QOL following endonasal endoscopic surgery, given the documented impact of age on QOL outcomes following transcranial resection of midline ventral skull base meningiomas.
We reviewed a prospectively acquired database of endonasal endoscopic surgery for meningiomas. Inclusion criteria included patients who had completed long-term postoperative (≥6 months follow-up) QOL questionnaires (Anterior Skull Base Questionnaire [ASBQ] and Sino-Nasal Outcome Test [SNOT-22]). Postoperative QOL scores were also compared with preoperative QOL in a patient subset.
Long-term QOL data were available in 34 patients. Average postoperative ASBQ and SNOT-22 scores were 3.39 and 23.0, respectively. Better QOL was statistically associated with age <55 (P = .02). In a subset of patients, preoperative and postoperative ASBQ and SNOT-22 scores were compared. Only SNOT-22 scores significantly increased from 15.9 + 20.8 to 25.9 + 19.5 (P = .04).
We report the first study specifically evaluating long-term QOL after endonasal endoscopic resection of skull base meningiomas. QOL was decreased postoperatively in patients aged ≥55.
ASBQ, Anterior Skull Base QuestionnaireGTR, gross total resectionQOL, quality of lifeSNOT-22, 22-item Sino-Nasal Outcome Test.
中线腹侧颅底脑膜瘤可能适合采用鼻内镜入路，与经颅入路相比，该入路具有理论优势，且可能有助于保留生活质量（QOL）。
鉴于年龄对经颅切除中线腹侧颅底脑膜瘤后生活质量结果有记录在案的影响，本研究旨在探讨年龄对鼻内镜手术后生活质量的影响。
我们回顾了一个前瞻性收集的脑膜瘤鼻内镜手术数据库。纳入标准包括完成术后长期（≥6个月随访）生活质量问卷（前颅底问卷[ASBQ]和鼻鼻窦结局测试[SNOT-22]）的患者。还对一部分患者的术后生活质量评分与术前生活质量进行了比较。
34例患者有长期生活质量数据。术后平均ASBQ和SNOT-22评分分别为3.39和23.0。生活质量较好与年龄<55岁有统计学关联（P = 0.02）。在一部分患者中，比较了术前和术后的ASBQ和SNOT-22评分。只有SNOT-22评分从15.9 + 20.8显著增加到25.9 + 19.5（P = 0.04）。
我们报告了第一项专门评估鼻内镜切除颅底脑膜瘤后长期生活质量的研究。≥55岁患者术后生活质量下降。
ASBQ，前颅底问卷；GTR，全切除；QOL，生活质量；SNOT-22，22项鼻鼻窦结局测试
