通过 Rh(II)催化的重氮芳基化反应，从芳基醚出发，模块化合成芳基乙酸酯、硫代酯和酰胺。
Modular Synthesis of Arylacetic Acid Esters, Thioesters, and Amides from Aryl Ethers via Rh(II)-Catalyzed Diazo Arylation.
机构信息
Université de Rennes 1, UMR CNRS 6226, Institut des Sciences Chimiques de Rennes, Equipe PNSCM, UFR des Sciences, Biologiques et Pharmaceutiques, 2 Avenue du Prof Leon Bernard, Rennes F-35043 Cedex, France.
出版信息
J Org Chem. 2016 Sep 2;81(17):7760-70. doi: 10.1021/acs.joc.6b01426. Epub 2016 Aug 9.
PMID:27465907
Abstract
One-pot formation of arylacetic acid esters, thioesters, and amides via Rh(II)-catalyzed arylation of a Meldrum's acid-derived diazo reagent with electron-rich arenes is described. The methodology was used to efficiently synthesize an anticancer compound.
摘要
一锅法合成芳基乙酸酯、硫代酯和酰胺，通过 Rh(II)催化 Meldrum's 酸衍生的重氮试剂与富电子芳环的芳基化反应。该方法用于高效合成一种抗癌化合物。
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