1p/19q共缺失少突胶质细胞瘤的骨髓转移——病例报告
Bone Marrow Metastases from a 1p/19q Co-deleted Oligodendroglioma - A Case Report.
作者信息
Demeulenaere Marieke, Duerinck Johnny, DU Four Stephanie, Fostier Karel, Michotte Alex, Neyns Bart
机构信息
Department of Medical Oncology, UZ Brussel, Brussels, Belgium.
Department of Neurosurgery, UZ Brussel, Brussels, Belgium.
出版信息
Anticancer Res. 2016 Aug;36(8):4145-9.
BACKGROUND
Metastasis of oligodendroglioma outside of the central nervous system (CNS) is a very rare event.
CASE
We describe in detail the clinical story of a 50-year-old woman diagnosed with profound pancytopenia and signs of extramedullary hematopoiesis caused by diffuse bone marrow replacement by a metastatic oligodendroglioma.
RESULTS
Upon development of pancytopenia, a diagnostic bone marrow examination revealed the presence of metastatic oligodendroglial cells. No others sites of malignant dissemination were found outside the CNS. Despite best supportive care, the patient died three weeks after diagnosis of myelophthisis.
CONCLUSION
Extracranial metastases from CNS oligodendroglioma are a very rare event but can be the cause of bone marrow failure.
背景
少突胶质细胞瘤转移至中枢神经系统（CNS）以外是非常罕见的事件。
病例
我们详细描述了一名50岁女性的临床病例，该患者被诊断为严重全血细胞减少症，且因转移性少突胶质细胞瘤弥漫性骨髓替代而出现髓外造血迹象。
结果
全血细胞减少症出现后，诊断性骨髓检查发现存在转移性少突胶质细胞。中枢神经系统以外未发现其他恶性播散部位。尽管给予了最佳支持治疗，但患者在诊断为骨髓痨后三周死亡。
结论
中枢神经系统少突胶质细胞瘤的颅外转移是非常罕见的事件，但可能是骨髓衰竭的原因。
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