DE Felice Francesca, Musio Daniela, Bulzonetti Nadia, Maghella Fabrizio, Tombolini Vincenzo
Department of Radiotherapy, Policlinico Umberto I "Sapienza" University of Rome, Rome, Italy
Department of Radiotherapy, Policlinico Umberto I "Sapienza" University of Rome, Rome, Italy.
Anticancer Res. 2016 Aug;36(8):4181-5.
To compare gross tumor volume (GTV) definition in locally advanced head and neck squamous cell carcinoma (LAHNSCC) using diffusion-weighted magnetic resonance imaging (DW-MRI) and computed tomography (CT) with intravenous contrast.
Patients with LAHNSCC were imaged with CT and DW-MRI before treatment. GTV was delineated in both CT and DW-MRI images by two investigators. CT and MRI images were co-registered and volume data were extracted for statistical analysis.
In general, DW-MRI volumes [based on the apparent diffusion coefficient (ADC)] were smaller than CT-based volumes. For all patients, GTV delineation based on pre-treatment DW-MRI was significantly smaller than that based on CT scan (CT-GTV) (p=0.0078). The mean difference (95% limits of agreement) between the two investigators was -0.37 cm(3) for CT-GTV and 0.17 cm(3) for ADC-GTV measurements, respectively.
DW-MRI radiotherapy GTVs are smaller than CT-based targets with less interobserver variability. Further validation of these preliminary results is necessary in a much larger patient group.
比较在局部晚期头颈部鳞状细胞癌（LAHNSCC）中使用扩散加权磁共振成像（DW-MRI）和静脉注射造影剂的计算机断层扫描（CT）来定义大体肿瘤体积（GTV）的情况。
LAHNSCC患者在治疗前接受CT和DW-MRI检查。由两名研究人员在CT和DW-MRI图像上勾画出GTV。将CT和MRI图像进行配准，并提取体积数据进行统计分析。
总体而言，基于表观扩散系数（ADC）的DW-MRI体积小于基于CT的体积。对于所有患者，基于治疗前DW-MRI勾画的GTV明显小于基于CT扫描（CT-GTV）勾画的GTV（p = 0.0078）。两名研究人员之间CT-GTV测量的平均差异（95%一致性界限）为-0.37 cm³，ADC-GTV测量的平均差异为0.17 cm³。
DW-MRI放疗GTV小于基于CT的靶区，且观察者间变异性较小。需要在更大的患者群体中对这些初步结果进行进一步验证。
