18F-氟二羟基苯丙氨酸正电子发射断层扫描/对比增强计算机断层扫描（18F-DOPA PET/CT）在疑似副神经节瘤患者中的临床价值

Clinical Value of 18F-fluorodihydroxyphenylalanine Positron Emission Tomography/Contrast-enhanced Computed Tomography (18F-DOPA PET/CT) in Patients with Suspected Paraganglioma.

作者信息

El-Rabadi Karem, Weber Michael, Mayerhofer Marius, Nakuz Thomas, Scherer Thomas, Mitterhauser Markus, Dudczak Robert, Hacker Marcus, Karanikas Georgios

机构信息

Division of General and Pediatric Radiology, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.

Division of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.

出版信息

Anticancer Res. 2016 Aug;36(8):4187-93.

PMID:27466530

Abstract

AIM

To evaluate (18)F-fluorodihydroxyphenylalanine-positron emission tomography/ contrast-enhanced computed tomography ((18)F-DOPA PET/CT) for the detection of paragangliomas (PARA) without any patient selection, such as genetic predisposition for the development of these tumors, history of metastatic PARA or hormonal status.

PATIENTS AND METHODS

In this retrospective study, 28 consecutive patients (15 women, 13 men; mean age=46.4 years; age range=19-73 years), who were referred to our PET/CT center for the detection of clinically suspected PARA, were included. Final diagnosis was confirmed by histological reports of surgically proven lesions and/or clinical follow-up (including laboratory results and/or PET/CT follow-up).

RESULTS

On a per-lesion basis (45 lesions) analysis, there was a sensitivity of 64.3% for CT, 73.8% for PET, 100% for PET/CT and a positive predictive value (PPV) of 93.1% for CT, 96.9% for PET and 100% for PET/CT. On a per-patient basis analysis, the sensitivity, specificity and accuracy for CT was 86.7%, 84.6% and 85.7%, respectively, and, for PET 80%, 100% and 89.3%, respectively, and, for PET/CT 100%.

CONCLUSION

Based on our data, (18)F-DOPA PET/CT is a "one-stop diagnostic modality" for the assessment of patients with suspected PARA.

摘要

目的

评估18F-氟二羟基苯丙氨酸正电子发射断层扫描/对比增强计算机断层扫描（18F-DOPA PET/CT）在不进行任何患者选择的情况下检测副神经节瘤（PARA）的能力，例如这些肿瘤发生的遗传易感性、转移性PARA病史或激素状态。

患者与方法

在这项回顾性研究中，纳入了28例连续患者（15例女性，13例男性；平均年龄=46.4岁；年龄范围=19 - 73岁），这些患者因临床怀疑患有PARA而被转诊至我们的PET/CT中心。最终诊断通过手术证实病变的组织学报告和/或临床随访（包括实验室检查结果和/或PET/CT随访）得以确认。

结果

基于每个病灶（共45个病灶）分析，CT的敏感性为64.3%，PET为73.8%，PET/CT为100%；CT的阳性预测值（PPV）为93.1%，PET为96.9%，PET/CT为100%。基于每位患者分析，CT的敏感性、特异性和准确性分别为86.7%、84.6%和85.7%，PET分别为80%、100%和89.3%，PET/CT为100%。