Patel Mayank, Jha Abhishek, Ling Alexander, Chen Clara C, Millo Corina, Kuo Mickey J M, Nazari Matthew A, Talvacchio Sara, Charles Kailah, Miettinen Markku, Del Rivero Jaydira, Chen Alice P, Nilubol Naris, Lin Frank I, Civelek Ali Cahid, Taïeb David, Carrasquillo Jorge A, Pacak Karel
Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20814, USA.
Radiology and Imaging Sciences, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20814, USA.
Cancers (Basel). 2022 Aug 11;14(16):3886. doi: 10.3390/cancers14163886.
The study identifies the importance of positron emission tomographic (PET) and anatomic imaging modalities and their individual performances in detecting succinate dehydrogenase A (-related metastatic pheochromocytoma and paraganglioma (PPGL). The detection rates of PET modalities-Ga-DOTATATE, F-FDG, and F-FDOPA-along with the combination of computed tomography (CT) and magnetic resonance imaging (MRI) are compared in a cohort of 11 patients with metastatic PPGL in the setting of a germline mutation. The imaging detection performances were evaluated at three levels: overall lesions, anatomic regions, and a patient-by-patient basis. Ga-DOTATATE PET demonstrated a lesion-based detection rate of 88.6% [95% confidence interval (CI), 84.3-92.5%], while F-FDG, F-FDOPA, and CT/MRI showed detection rates of 82.9% (CI, 78.0-87.1%), 39.8% (CI, 30.2-50.2%), and 58.2% (CI, 52.0-64.1%), respectively. The study found that Ga-DOTATATE best detects lesions in a subset of patients with related metastatic PPGL. However, F-FDG did detect more lesions in the liver, mediastinum, and abdomen/pelvis anatomic regions, showing the importance of a combined approach using both PET modalities in evaluating -related PPGL.
该研究确定了正电子发射断层扫描（PET）和解剖成像模式的重要性及其在检测琥珀酸脱氢酶A相关转移性嗜铬细胞瘤和副神经节瘤（PPGL）中的个体表现。在一组11例患有种系突变的转移性PPGL患者中，比较了PET模式（镓-多柔比星、氟代脱氧葡萄糖和氟代多巴）以及计算机断层扫描（CT）和磁共振成像（MRI）联合使用的检测率。在三个层面评估成像检测性能：整体病变、解剖区域和逐个患者层面。镓-多柔比星PET显示基于病变的检测率为88.6%[95%置信区间（CI），84.3-92.5%]，而氟代脱氧葡萄糖、氟代多巴和CT/MRI的检测率分别为82.9%（CI，78.0-87.1%）、39.8%（CI，30.2-50.2%）和58.2%（CI，52.0-64.1%）。该研究发现，镓-多柔比星在相关转移性PPGL患者亚组中对病变的检测效果最佳。然而，氟代脱氧葡萄糖确实在肝脏、纵隔和腹部/盆腔解剖区域检测到更多病变，这表明在评估相关PPGL时联合使用两种PET模式的重要性。
