Meeks Marshall W, Grace Shane, Chen Yongxin, Petterchak James, Bolesta Edward, Zhou Yihua, Lai Jin-Ping
Department of Pathology, Saint Louis University School of Medicine, Saint Louis, MO, U.S.A.
Department of Radiology, Saint Louis University School of Medicine, Saint Louis, MO, U.S.A.
Anticancer Res. 2016 Aug;36(8):4307-11.
Quadruple synchronous primary neoplasms are very rare with only three cases reported in the English-speaking literature to date. Collision tumors are also rare entities, especially of the appendix. We herein report a case of synchronous quadruple primary neoplasm in a 95-year-old female. She was diagnosed with colon adenocarcinoma, sessile serrated adenoma of the appendix and a collision tumor composed of a well-differentiated neuroendocrine tumor and Schwann cell hamartoma. Histological examination and immunohistochemistry supported these four lesions as separate entities. This case is unique because we report the diagnosis of quadruple synchronous primary, an extremely rare occurrence, in addition to a collision tumor of the appendix. We also provide a review of the literature for synchronous neoplasms and collision tumors.
四重同步原发性肿瘤非常罕见，迄今为止英文文献中仅报道过3例。碰撞瘤也是罕见的实体瘤，尤其是阑尾碰撞瘤。我们在此报告一例95岁女性的同步四重原发性肿瘤病例。她被诊断患有结肠腺癌、阑尾无蒂锯齿状腺瘤以及由高分化神经内分泌肿瘤和施万细胞错构瘤组成的碰撞瘤。组织学检查和免疫组化证实这四个病变为独立的实体。该病例独特之处在于，我们报告了极其罕见的四重同步原发性肿瘤的诊断，此外还有阑尾碰撞瘤。我们还提供了关于同步肿瘤和碰撞瘤的文献综述。
