Strick Reiner, Strissel Pamela L, Baylin Stephen B, Chiappinelli Katherine B
Department of Gynecology and Obstetrics, Laboratory for Molecular Medicine, Friedrich-Alexander University Erlangen-Nürnberg (FAU), University-Clinic Erlangen , Erlangen, Germany.
Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins , Baltimore, MD, USA.
Oncoimmunology. 2015 Dec 29;5(5):e1122160. doi: 10.1080/2162402X.2015.1122160. eCollection 2016 May.
Loss of DNA methylation can activate endogenous retroviral expression and dsRNA in cancer cells. This leads to induction of toll-like receptor signaling stimulating an antiviral interferon response. Recent findings provide a therapeutic rationale for combining DNA methylation inhibitors with blockage of immune checkpoint proteins to fight cancer.
DNA甲基化的缺失可激活癌细胞中的内源性逆转录病毒表达和双链RNA。这会导致Toll样受体信号的诱导,刺激抗病毒干扰素反应。最近的研究结果为联合使用DNA甲基化抑制剂和阻断免疫检查点蛋白来对抗癌症提供了治疗依据。