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Unraveling the molecular pathways of DNA-methylation inhibitors: human endogenous retroviruses induce the innate immune response in tumors.
Oncoimmunology. 2015 Dec 29;5(5):e1122160. doi: 10.1080/2162402X.2015.1122160. eCollection 2016 May.
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An endogenous retroviral element exerts an antiviral innate immune function via the derived lncRNA lnc-ALVE1-AS1.
Antiviral Res. 2019 Oct;170:104571. doi: 10.1016/j.antiviral.2019.104571. Epub 2019 Jul 30.
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The immunomodulatory anticancer agent, RRx-001, induces an interferon response through epigenetic induction of viral mimicry.
Clin Epigenetics. 2017 Jan 19;9:4. doi: 10.1186/s13148-017-0312-z. eCollection 2017.
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A New Molecular Mechanism Underlying the Antitumor Effect of DNA Methylation Inhibitors via an Antiviral Immune Response.
Adv Protein Chem Struct Biol. 2017;106:227-242. doi: 10.1016/bs.apcsb.2016.08.005. Epub 2016 Sep 23.
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HERVs New Role in Cancer: From Accused Perpetrators to Cheerful Protectors.
Front Microbiol. 2018 Feb 13;9:178. doi: 10.3389/fmicb.2018.00178. eCollection 2018.
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Mechanisms and pathways of innate immune activation and regulation in health and cancer.
Hum Vaccin Immunother. 2014;10(11):3270-85. doi: 10.4161/21645515.2014.979640.

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Reactivated endogenous retroviruses promote protein aggregate spreading.
Nat Commun. 2023 Aug 18;14(1):5034. doi: 10.1038/s41467-023-40632-z.
2
Role of Transposable Elements in Genome Stability: Implications for Health and Disease.
Int J Mol Sci. 2022 Jul 15;23(14):7802. doi: 10.3390/ijms23147802.
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A Therapeutic Whole-Tumor-Cell Vaccine Covalently Conjugated with a TLR7 Agonist.
Cells. 2022 Jun 21;11(13):1986. doi: 10.3390/cells11131986.
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Epigenetic Drugs and Their Immune Modulating Potential in Cancers.
Biomedicines. 2022 Jan 19;10(2):211. doi: 10.3390/biomedicines10020211.
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Human Endogenous Retrovirus Reactivation: Implications for Cancer Immunotherapy.
Cancers (Basel). 2021 Apr 21;13(9):1999. doi: 10.3390/cancers13091999.
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Adaptive Mechanisms of Tumor Therapy Resistance Driven by Tumor Microenvironment.
Front Cell Dev Biol. 2021 Mar 1;9:641469. doi: 10.3389/fcell.2021.641469. eCollection 2021.
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Endogenous Double-Stranded RNA.
Noncoding RNA. 2021 Feb 19;7(1):15. doi: 10.3390/ncrna7010015.
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Response of human macrophages to gamma radiation is mediated via expression of endogenous retroviruses.
PLoS Pathog. 2021 Feb 8;17(2):e1009305. doi: 10.1371/journal.ppat.1009305. eCollection 2021 Feb.
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Transposable element regulation and expression in cancer.
FEBS J. 2022 Mar;289(5):1160-1179. doi: 10.1111/febs.15722. Epub 2021 Feb 13.
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Long non-coding RNA levels can be modulated by 5-azacytidine in Schistosoma mansoni.
Sci Rep. 2020 Dec 9;10(1):21565. doi: 10.1038/s41598-020-78669-5.

本文引用的文献

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Toll-like receptors: Activation, signalling and transcriptional modulation.
Cytokine. 2015 Aug;74(2):181-9. doi: 10.1016/j.cyto.2015.02.025. Epub 2015 Apr 3.
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Immune Checkpoint Blockade in Cancer Therapy.
J Clin Oncol. 2015 Jun 10;33(17):1974-82. doi: 10.1200/JCO.2014.59.4358. Epub 2015 Jan 20.
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The innate immune sensor LGP2 activates antiviral signaling by regulating MDA5-RNA interaction and filament assembly.
Mol Cell. 2014 Sep 4;55(5):771-81. doi: 10.1016/j.molcel.2014.07.003. Epub 2014 Aug 7.
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Pattern Recognition and Signaling Mechanisms of RIG-I and MDA5.
Front Immunol. 2014 Jul 23;5:342. doi: 10.3389/fimmu.2014.00342. eCollection 2014.
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The history of Toll-like receptors - redefining innate immunity.
Nat Rev Immunol. 2013 Jun;13(6):453-60. doi: 10.1038/nri3446. Epub 2013 May 17.
9
Nucleic acid-sensing Toll-like receptors are essential for the control of endogenous retrovirus viremia and ERV-induced tumors.
Immunity. 2012 Nov 16;37(5):867-79. doi: 10.1016/j.immuni.2012.07.018. Epub 2012 Nov 8.
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Synthetic double-stranded RNA induces innate immune responses similar to a live viral vaccine in humans.
J Exp Med. 2011 Nov 21;208(12):2357-66. doi: 10.1084/jem.20111171. Epub 2011 Nov 7.

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