使用渗透泵输注阿米卡星治疗泰勒氏矛头蝮（Agkistrodon bilineatus taylori）由肠炎沙门氏菌霍滕亚种引起的骨髓炎

MANAGEMENT OF OSTEOMYELITIS CAUSED BY SALMONELLA ENTERICA SUBSP. HOUTENAE IN A TAYLOR'S CANTIL (AGKISTRODON BILINEATUS TAYLORI) USING AMIKACIN DELIVERED VIA OSMOTIC PUMP.

作者信息

Clancy Meredith M, Newton Alisa L, Sykes John M

出版信息

J Zoo Wildl Med. 2016 Jun;47(2):691-4. doi: 10.1638/2015-0207.1.

DOI:10.1638/2015-0207.1

Abstract

An adult female Taylor's cantil (Agkistrodon bilineatus taylori) presented with marked spinal and mandibular osteomyelitis that cultured positive for Salmonella enterica subsp. houtenae, serovar IV 43:z4,z32:-. Progression of osteomyelitis was arrested by treatment using amikacin (0.026 mg/kg per hour) delivered via subcutaneous osmotic pump for 10 mo, replacing the pump every 4 wk. No adverse effects on renal function were appreciated throughout the course of therapy. Amikacin therapy was discontinued after improvement with treatment, but 5 mo later, bony lesions worsened, and an additional abscess formed at the previous pump site. The animal's condition declined and euthanasia was elected. Postmortem examination confirmed marked osteomyelitis with Salmonella infection of same serovar as the initial biopsy. This report highlights the pathogenicity of the S. enterica subsp. houtenae serovar and the ability to deliver effective amikacin dosage via osmotic pump to arrest osteomyelitis due to salmonellosis in a venomous snake.

摘要

一只成年雌性泰勒氏矛头蝮（Agkistrodon bilineatus taylori）出现明显的脊柱和下颌骨髓炎，经培养，感染了肠炎沙门氏菌亚种豪滕亚种（Salmonella enterica subsp. houtenae），血清型为IV 43:z4,z32:-。通过皮下渗透泵以每小时0.026毫克/千克的剂量给予阿米卡星治疗10个月，每4周更换一次泵，骨髓炎的进展得到了控制。在整个治疗过程中，未发现对肾功能有不良影响。经治疗病情改善后，停用了阿米卡星治疗，但5个月后，骨病变恶化，且在先前泵植入部位形成了一个额外的脓肿。该动物的状况恶化，最终选择实施安乐死。尸检证实存在明显的骨髓炎，感染的沙门氏菌血清型与最初活检时相同。本报告强调了肠炎沙门氏菌亚种豪滕亚种血清型的致病性，以及通过渗透泵给予有效剂量的阿米卡星以控制毒蛇沙门氏菌病所致骨髓炎的能力。