Department of Neurology, Texas A&M Small Animal Hospital, 408 Raymond Stotzer Pkwy, College Station, TX, 77845, USA.
Department of Veterinary Pathobiology, Texas A&M Small Animal Hospital, 408 Raymond Stotzer Pkwy, College Station, TX, 77845, USA.
BMC Vet Res. 2020 Nov 11;16(1):437. doi: 10.1186/s12917-020-02652-5.
We report the first case of canine Salmonella meningoencephalomyelitis and second case of canine Salmonella bacteriuria, as well as the first reported case of Salmonella enterica subspecies houtenae in a dog.
Immunosuppressive treatment in a dog for a relapse of steroid-responsive meningitis and arteritis (SRMA) allowed for the opportunistic establishment of a bacteremia with Salmonella enterica subsp. houtenae, ultimately causing meningoencephalomyelitis and subclinical bacteriuria. The bacterial infections were treated with a four-month course of amoxicillin; clinical treatment success was determined by serial negative urine cultures and lack of clinical signs correlated to the meningoencephalomyelitis.
Both the bacteriuria and meningoencephalomyelitis represented opportunistic infections in a dog immunosuppressed for SRMA. The clinical course of this infectious meningoencephalitis emphasizes the importance of differentiating relapse of initial disease from opportunistic infection occurring in a compromised central nervous system. The novel Salmonella species identified in this case acts as a reminder that infectious disease diagnostics should not be curbed by anecdotal prediction of routine pathogenic suspects.
我们报告了首例犬沙门氏菌脑膜脑炎和第二例犬沙门氏菌菌尿症，以及首例犬肠炎沙门氏菌亚种 houtenae 的报告。
为复发的类固醇反应性脑膜炎和动脉炎（SRMA）的犬进行免疫抑制治疗，使肠炎沙门氏菌亚种 houtenae 机会性菌血症得以建立，最终导致脑膜脑炎和亚临床菌尿症。细菌感染用阿莫西林治疗四个月；临床治疗成功通过连续的阴性尿液培养和与脑膜脑炎无关的临床症状来确定。
在因 SRMA 而免疫抑制的犬中，菌尿症和脑膜脑炎均为机会性感染。这种感染性脑膜脑炎的临床过程强调了区分初始疾病的复发与中枢神经系统受损时发生的机会性感染的重要性。在这种情况下确定的新型沙门氏菌提醒我们，传染病诊断不应受到常规致病性推测的轶事预测的限制。
