Tucson Pathology Associates, PC Carondelet Saint Joseph Hospital, 351 North Wilmot Road, Tucson, AZ 85711 USA.
Department of Hematology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300060 China.
Biomark Res. 2016 Jul 27;4:15. doi: 10.1186/s40364-016-0068-1. eCollection 2016.
Helicobacter pylori (H. pylori)-associated gastritis is one of the most common infectious diseases in the United States, China and worldwide. Gastric mucosa-associated tissue lymphoma (MALT lymphoma) is a rare mature B-cell neoplasm associated with H. pylori infection that is curable by antibiotics therapy alone. The pathological diagnosis of gastric MALT lymphoma can be reached by histological examination, immunohistochemical staining and B-cell clonality analysis. H. pylori eradication is the choice of therapy for early-stage gastric MALT lymphoma. High response rates and long-term survival have been reported in refractory and localized diseases treated with low-dose radiation therapy. Systemic chemotherapy is recommended for advanced-stage gastric MALT lymphoma and cases with large B-cell lymphoma transformation. Recent advances in the pathological diagnosis and management of gastric MALT lymphoma are reviewed in this article.
幽门螺杆菌（H. pylori）相关性胃炎是美国、中国和全球最常见的传染病之一。胃黏膜相关组织淋巴瘤（MALT 淋巴瘤）是一种罕见的成熟 B 细胞肿瘤，与 H. pylori 感染相关，单独使用抗生素治疗即可治愈。通过组织学检查、免疫组织化学染色和 B 细胞克隆性分析可做出胃 MALT 淋巴瘤的病理诊断。早期胃 MALT 淋巴瘤的治疗选择是 H. pylori 根除。对于难治性和局限性疾病，采用低剂量放射治疗可获得高缓解率和长期生存。对于晚期胃 MALT 淋巴瘤和大 B 细胞淋巴瘤转化的病例，建议进行全身化疗。本文就胃 MALT 淋巴瘤的病理诊断和治疗进展进行综述。
