Xiao Li-juan, Yang Zheng, Man Yi, Hao Liang, Wang Min, Li Guang-da, Liu Hao
Sichuan Da Xue Xue Bao Yi Xue Ban. 2016 May;47(3):360-4.
To determine the effects of gelatin on the performance of calcium phosphate cement (CPC).
α-tricalcium phosphate (α-TCP) bone cement was mixed with different concentrations of gelatin solutions. The CPC samples were soaked into simulated body fluid for one day before their compressive and bending strengths were measured. We also compared their waterproof performance, solidification time and surface topography.
Gelatin solutions changed the performance of CPC. Optimal performance of CPC was achieved when the volume ratio of gelatin solution to CPC (Vgelatin solution:V(CPC liquid)) was set at 25:100, which increased compressive strength from (7.874 54 ± 0.660 97) MPa to (9.936 52 ± 0.433 17) MPa and bending strength from (5.157 06 ± 0.298 30) MPa to (7.959 71 ± 0.281 63) MPa. Gelatin solution also prolonged setting time of CPC, improved its waterproof performance, and promoted formulation of more dense and uniform hydroxyapatite crystals.
Gelatin can improve the compressive and bending strengths of CPC, and make CPC more suitable for clinic use through improvements in setting time and waterproof performance.
确定明胶对磷酸钙骨水泥（CPC）性能的影响。
将α-磷酸三钙（α-TCP）骨水泥与不同浓度的明胶溶液混合。将CPC样品浸泡在模拟体液中一天，然后测量其抗压强度和抗弯强度。我们还比较了它们的防水性能、固化时间和表面形貌。
明胶溶液改变了CPC的性能。当明胶溶液与CPC的体积比（V明胶溶液:V（CPC液体））设定为25:100时，CPC达到最佳性能，抗压强度从（7.874 54±0.660 97）MPa提高到（9.936 52±0.433 17）MPa，抗弯强度从（5.157 06±0.298 30）MPa提高到（7.959 71±0.281 63）MPa。明胶溶液还延长了CPC的固化时间，提高了其防水性能，并促进了更致密均匀的羟基磷灰石晶体的形成。
明胶可以提高CPC的抗压强度和抗弯强度，并通过改善固化时间和防水性能使CPC更适合临床使用。
