Takeda E, Hosoda T, Ichioka T, Miyao M
Department of Pediatrics, School of Medicine, University of Tokushima.
Jpn J Antibiot. 1989 Mar;42(3):725-31.
A combination drug of sulbactam/ampicillin (SBT/ABPC) was intravenously administrated to 18 patients with ages 3 months to 10 years 10 months with various acute infections including 14 cases of pneumonia, 1 case each of tonsillitis, subacute bacterial endocarditis, empyema and suspected sepsis. Clinical responses were excellent in 14 cases and good in 4 cases. Bacteriological responses of 8 isolated strains were: 7 strains were eradicated and 1 strain was decreased. No side effect was observed in any case. Eosinophilia was observed in 2 cases, thrombocytosis in 2 cases, elevation of GOT in 1 case and elevations of GOT and GPT in 1 case. From the above results, it seemed that SBT/ABPC was a useful drug for the treatment of bacterial infections in the pediatric field.
对18例年龄在3个月至10岁10个月的患有各种急性感染的患儿静脉注射舒巴坦/氨苄西林联合制剂（SBT/ABPC），其中包括14例肺炎、1例扁桃体炎、1例亚急性细菌性心内膜炎、1例脓胸和1例疑似败血症。临床反应14例为优，4例为良。8株分离菌株的细菌学反应为：7株被根除，1株减少。未观察到任何副作用。2例出现嗜酸性粒细胞增多，2例出现血小板增多，1例谷草转氨酶（GOT）升高，1例GOT和谷丙转氨酶（GPT）均升高。从上述结果来看，SBT/ABPC似乎是治疗儿科领域细菌感染的一种有效药物。
