Díaz Diana B, Brandon Thomas H, Sutton Steven K, Meltzer Lauren R, Hoehn Hannah J, Meade Cathy D, Jacobsen Paul B, McCaffrey Judith C, Haura Eric B, Lin Hui-Yi, Simmons Vani N
H. Lee Moffitt Cancer Center & Research Institute, 12902 USF Magnolia Drive, Tampa, FL 33612, United States.
H. Lee Moffitt Cancer Center & Research Institute, 12902 USF Magnolia Drive, Tampa, FL 33612, United States; University of South Florida, 4202 E. Fowler Avenue, Tampa, FL 33620, United States.
Contemp Clin Trials. 2016 Sep;50:84-9. doi: 10.1016/j.cct.2016.07.015. Epub 2016 Jul 25.
Continued smoking after a cancer diagnosis contributes to several negative health outcomes. Although many cancer patients attempt to quit smoking, high smoking relapse rates have been observed. This highlights the need for a targeted, evidence-based smoking-relapse prevention intervention. The design, method, and baseline characteristics of a randomized controlled trial assessing the efficacy of a self-help smoking-relapse prevention intervention are presented. Cancer patients who had recently quit smoking were randomized to one of two conditions. The Usual Care (UC) group received the institution's standard of care. The smoking relapse-prevention intervention (SRP) group received standard of care, plus 8 relapse-prevention booklets mailed over a 3month period, and a targeted educational DVD developed specifically for cancer patients. Four hundred and fourteen participants were enrolled and completed a baseline survey. Primary outcomes will be self-reported smoking status at 6 and 12-months after baseline. Biochemical verification of smoking status was completed for a subsample. If found to be efficacious, this low-cost intervention could be easily disseminated with significant potential for reducing the risk of negative cancer outcomes associated with continued smoking.
癌症诊断后继续吸烟会导致多种负面健康后果。尽管许多癌症患者试图戒烟，但观察到吸烟复发率很高。这凸显了需要一种有针对性的、基于证据的预防吸烟复发干预措施。本文介绍了一项评估自助式预防吸烟复发干预措施效果的随机对照试验的设计、方法和基线特征。近期戒烟的癌症患者被随机分为两种情况之一。常规护理（UC）组接受机构的标准护理。预防吸烟复发干预（SRP）组接受标准护理，外加在3个月内邮寄的8本预防复发手册，以及专门为癌症患者制作的有针对性的教育DVD。414名参与者被招募并完成了基线调查。主要结局将是基线后6个月和12个月时自我报告的吸烟状况。对一个子样本完成了吸烟状况的生化验证。如果被证明有效，这种低成本干预措施可以很容易地推广，具有显著潜力降低与持续吸烟相关的负面癌症结局风险。
