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在肿瘤引流肺静脉中检测到的循环肿瘤细胞与非小细胞肺癌手术切除后的疾病复发相关。

Circulating Tumor Cells Detected in the Tumor-Draining Pulmonary Vein Are Associated with Disease Recurrence after Surgical Resection of NSCLC.

作者信息

Crosbie Phil A J, Shah Rajesh, Krysiak Piotr, Zhou Cong, Morris Karen, Tugwood Jonathan, Booton Richard, Blackhall Fiona, Dive Caroline

机构信息

Manchester Thoracic Oncology Centre, North West Lung Centre, University Hospital of South Manchester, Manchester, United Kingdom; Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute, Manchester, United Kingdom; Cancer Research UK Lung Cancer Centre of Excellence, Manchester, United Kingdom.

Manchester Thoracic Oncology Centre, North West Lung Centre, University Hospital of South Manchester, Manchester, United Kingdom; Cancer Research UK Lung Cancer Centre of Excellence, Manchester, United Kingdom; Department of Thoracic Surgery, University Hospital of South Manchester, Manchester, United Kingdom.

出版信息

J Thorac Oncol. 2016 Oct;11(10):1793-7. doi: 10.1016/j.jtho.2016.06.017. Epub 2016 Jul 25.

DOI:10.1016/j.jtho.2016.06.017
PMID:27468936
原文链接:
https://pmc.ncbi.nlm.nih.gov/articles/PMC5063509/
Abstract

Tumor recurrence after surgical resection of NSCLC obstructs long-term disease-free survival in approximately 50% of cases. Our data suggest that combining circulating tumor cell enumeration (as single cells or clusters) in tumor-draining pulmonary vein and peripheral blood (assessed by CellSearch) at the time of NSCLC surgery better identifies those patients at higher risk for lung cancer recurrence than does peripheral circulating tumor cell number alone.

摘要

非小细胞肺癌手术切除后的肿瘤复发阻碍了约50%病例的长期无病生存。我们的数据表明，在非小细胞肺癌手术时，结合肿瘤引流肺静脉和外周血中循环肿瘤细胞计数（作为单个细胞或细胞簇，通过CellSearch评估）比单独的外周循环肿瘤细胞数量能更好地识别那些肺癌复发风险较高的患者。

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Tracking genomic cancer evolution for precision medicine: the lung TRACERx study.追踪基因组癌症演变以实现精准医疗：肺癌TRACERx研究。
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Tumorigenicity and genetic profiling of circulating tumor cells in small-cell lung cancer.小细胞肺癌循环肿瘤细胞的致瘤性和基因谱分析。
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Significant increase in circulating tumour cells in pulmonary venous blood during surgical manipulation in patients with primary lung cancer.
细胞液体活检为罕见唾液腺癌患者的疾病监测、临床前模型生成和治疗调整提供了独特的机会。
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Clinical Implications of Circulating Tumor Cells in Patients with Esophageal Squamous Cell Carcinoma: Cancer-Draining Blood Versus Peripheral Blood.食管鳞状细胞癌患者循环肿瘤细胞的临床意义：引流癌组织血液与外周血的比较
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