Wang Xiaochen, Bai Lu, Kong Linghui, Guo Zhijuan
Department of Pathology and Pathophysiology, Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.
Department of Pathology, Cancer Hospital Affiliated to Inner Mongolia Medical University / Peking University Cancer Hospital Inner Mongolia Hospital, Hohhot, Inner Mongolia, China.
Front Oncol. 2024 Jun 21;14:1411731. doi: 10.3389/fonc.2024.1411731. eCollection 2024.
Globally, lung cancer stands as the leading type of cancer in terms of incidence and is the major source of mortality attributed to cancer. We have outlined the molecular biomarkers for lung cancer that are available clinically. Circulating tumor cells (CTCs) spread from the original location, circulate in the bloodstream, extravasate, and metastasize, forming secondary tumors by invading and establishing a favorable environment. CTC analysis is considered a common liquid biopsy method for lung cancer. We have enumerated both and ex vivo techniques for CTC separation and enrichment, examined the advantages and limitations of these methods, and also discussed the detection of CTCs in other bodily fluids. We have evaluated the value of CTCs, as well as CTCs in conjunction with other biomarkers, for their utility in the early detection and prognostic assessment of patients with lung cancer. CTCs engage with diverse cells of the metastatic process, interfering with the interaction between CTCs and various cells in metastasis, potentially halting metastasis and enhancing patient prognosis.
在全球范围内，肺癌在发病率方面是主要的癌症类型，并且是癌症致死的主要原因。我们已经概述了临床上可用的肺癌分子生物标志物。循环肿瘤细胞（CTC）从原发部位扩散，在血液中循环，外渗并转移，通过侵入并建立有利环境形成继发性肿瘤。CTC分析被认为是一种常见的肺癌液体活检方法。我们列举了体内和体外CTC分离与富集技术，研究了这些方法的优缺点，还讨论了在其他体液中检测CTC的情况。我们评估了CTC以及CTC与其他生物标志物结合在肺癌患者早期检测和预后评估中的效用。CTC参与转移过程中的多种细胞相互作用，干扰CTC与转移过程中各种细胞之间的相互作用，有可能阻止转移并改善患者预后。
