Li Xiaoxiao, Ye Sujuan, Luo Xiliang
Key Laboratory of Sensor Analysis of Tumor Marker, Ministry of Education, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P. R. China.
Chem Commun (Camb). 2016 Aug 11;52(67):10269-72. doi: 10.1039/c6cc04391g.
In this work, an enzyme-free signal amplified detection platform is described for miRNA detection with a DNA fueled molecular machine. Coupling SERS technology with multiple amplification modes, this flexible biosensing system exhibits high sensitivity and specificity.