一种 DNA 连接子-DNA 双功能探针，通过对称信号放大实现 miRNA 的同时 SERS 检测。
A DNA-linker-DNA bifunctional probe for simultaneous SERS detection of miRNAs via symmetric signal amplification.
机构信息
Key Laboratory of Sensor Analysis of Tumor Marker, Ministry of Education, State Key Laboratory Base of Eco-chemical Engineering, Shandong Key Laboratory of biochemical Analysis, Key Laboratory of Life Analytical Chemistry in Universities of Shandong, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P. R. China.
出版信息
Chem Commun (Camb). 2018 Jul 10;54(56):7786-7789. doi: 10.1039/c8cc02910e.
In this work, using a dual functional DNA-linker-DNA (DLD) probe, a new concept of a symmetric signal amplification (SSA) reaction is introduced to simultaneously analyze miRNAs. By coupling the surface-enhanced Raman scattering (SERS) technology with symmetric amplification modes, this flexible biosensing system exhibits high sensitivity and specificity.
在这项工作中，我们使用了一种双重功能的 DNA 连接子-DNA（DLD）探针，引入了一种新的对称信号放大（SSA）反应概念，用于同时分析 microRNA。通过将表面增强拉曼散射（SERS）技术与对称放大模式相结合，这种灵活的生物传感系统表现出了高灵敏度和特异性。
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