Department of Medicine and Surgery, University of Milan-Bicocca, Milan, Italy.
Department of Chemistry, University of Ferrara, Ferrara, Italy.
J Biol Regul Homeost Agents. 2016 Apr-Jun;30(2 Suppl 1):123-8.
The use of chemical devices for non-surgical periodontal therapy has led to new treatment strategies aiming primarily at infection control and oral bacterial load. Over the last few decades adjunctive chemical devices has been subjected to many scientific and medical studies. The purpose of the present study was to assess the effect of a new oral gel named Parodongel on the red complex organisms using Polymerase Chain Reaction (PCR) for microbiological analysis. A total of 10 patients with a diagnosis of chronic periodontitis in the age group >25 years, were selected. None of these patients had received any surgical or non-surgical periodontal therapy and demonstrated radiographic evidence of moderate bone loss. Four non-adjacent sites in separate quadrants were selected in each patient for monitoring based on criteria that the sites will localize chronic periodontitis. Microbial analysis (MA) was performed at baseline and at day 15. Paired T-Test was used to detect statistical significant reduction of specific bacteria. The results showed statistically significant reduction of the overall bacterial loading and Treponema Denticola from baseline to day 15. Parodongel can be used as an effective local drug delivery together with oral home care in treatment of chronic periodontitis.
化学器械在非手术性牙周治疗中的应用催生了新的治疗策略，主要针对感染控制和口腔细菌负荷。在过去几十年中，辅助化学器械已经接受了许多科学和医学研究。本研究旨在使用聚合酶链反应（PCR）微生物分析评估一种名为 Parodongel 的新型口腔凝胶对红色复合体生物的影响。共选择了 10 名年龄>25 岁的慢性牙周炎患者。这些患者均未接受任何手术或非手术性牙周治疗，影像学显示有中度骨丧失。每位患者在四个不同象限的四个非相邻部位根据定位慢性牙周炎的标准选择进行监测。在基线和第 15 天进行微生物分析（MA）。使用配对 T 检验检测特定细菌的统计学显著减少。结果表明，从基线到第 15 天，总体细菌负荷和密螺旋体显著减少。Parodongel 可与口腔家庭护理一起作为治疗慢性牙周炎的有效局部药物输送。
