Shimizu K, Shibata M
Nihon Jinzo Gakkai Shi. 1989 Apr;31(4):345-51.
Daunomycin rats are frequently used as an experimental model of nephrotic syndrome. We accidentally left daunomycin rats for a long time, and after death, these rats showed extensive scarring of the kidney. Since then, we have been studying whether daunomycin rats can be used as an experimental model of chronic renal failure. Female Wistar rats were injected i.v. with a single dose of daunomycin 12 mg/kg or 6 mg/kg body wt. We then observed the rats for six months. The rats in the 12 mg/kg injection group died within three to six months. All rats died from chronic renal failure. The BUN and creatinine levels significantly increased from seven weeks after daunomycin 12 mg/kg injection. At the end stage, renal anemia and hyperphosphatemia were noticed. There was an inverse relationship between the life span of daunomycin rats and urine protein level at four weeks. Rats with a large amount of urine protein at four weeks died of uremia at an early age. We concluded that daunomycin rats can be used as an experimental model of chronic renal failure.
柔红霉素大鼠常被用作肾病综合征的实验模型。我们意外地将柔红霉素大鼠放置了很长时间，这些大鼠死后，肾脏出现了广泛的瘢痕形成。从那时起，我们一直在研究柔红霉素大鼠是否可作为慢性肾衰竭的实验模型。对雌性Wistar大鼠静脉注射单剂量12 mg/kg或6 mg/kg体重的柔红霉素。然后我们对大鼠进行了六个月的观察。12 mg/kg注射组的大鼠在三到六个月内死亡。所有大鼠均死于慢性肾衰竭。在注射12 mg/kg柔红霉素后七周，血尿素氮（BUN）和肌酐水平显著升高。在终末期，出现了肾性贫血和高磷血症。柔红霉素大鼠的寿命与四周时的尿蛋白水平呈负相关。四周时尿蛋白量大的大鼠早年死于尿毒症。我们得出结论，柔红霉素大鼠可作为慢性肾衰竭的实验模型。
