Shimizu K, Maeda K, Shibata M, Ise M, Sugano M, Uehara Y
Aichi Prefectural Women's Junior College, Nagoya, Japan.
Nihon Jinzo Gakkai Shi. 1990 Aug;32(8):863-9.
We examined whether daunomycin rats could be used as an experimental model of human chronic renal failure in terms of their osseous changes and mineral metabolism. The daunomycin rats revealed hyperphosphatemia and osteodystrophic bone changes. In this respect, they were similar to human chronic renal failure. A high calcium level was found in the daunomycin rats at first due to the effect of the daunomycin injection, but later there was a lower calcium level than in the control rats due to chronic renal failure. We conclude that daunomycin rats can be successfully used as an experimental model of chronic renal failure from the standpoint of their osseous changes and mineral metabolism.
我们从骨变化和矿物质代谢方面研究了柔红霉素大鼠是否可作为人类慢性肾衰竭的实验模型。柔红霉素大鼠出现高磷血症和骨营养不良性骨变化。在这方面，它们与人类慢性肾衰竭相似。起初，由于柔红霉素注射的作用，柔红霉素大鼠体内钙水平较高，但后来由于慢性肾衰竭，其钙水平低于对照大鼠。我们得出结论，从骨变化和矿物质代谢的角度来看，柔红霉素大鼠可成功用作慢性肾衰竭的实验模型。
