通过将过继性T细胞疗法与鼠伤寒沙门氏菌联合使用来预防肿瘤复发。
Tumor relapse prevented by combining adoptive T cell therapy with Salmonella typhimurium.
作者信息
Binder David C, Arina Ainhoa, Wen Frank, Tu Tony, Zhao Ming, Hoffman Robert M, Wainwright Derek A, Schreiber Hans
机构信息
Committee on Cancer Biology, University of Chicago, Chicago, IL, USA; Department of Pathology, University of Chicago, Chicago, IL, USA.
Department of Pathology, University of Chicago, Chicago, IL, USA; Committee on Immunology, The University of Chicago, Chicago, IL, USA.
出版信息
Oncoimmunology. 2016 Feb 18;5(6):e1130207. doi: 10.1080/2162402X.2015.1130207. eCollection 2016 Jun.
Abstract
We recently reported that therapeutic vaccination with live tumor antigen-producing Salmonella typhimurium rescues dysfunctional endogenous T cell responses and eradicates long-established tumors refractory to αCTLA-4 and αPD-L1 checkpoint inhibitor blockade. Here, we show that live intravenously injected or heat-killed (HK) intratumorally injected Salmonella typhimurium, even when not producing tumor antigen, synergize with adoptive T cell therapy to eradicate tumors. These data demonstrate that the combination of adoptive T cell transfer with the injection of live or dead Salmonella typhimurium is a promising approach for cancer treatment.
摘要
我们最近报道，用产生活肿瘤抗原的鼠伤寒沙门氏菌进行治疗性疫苗接种可挽救功能失调的内源性T细胞反应，并根除对αCTLA-4和αPD-L1检查点抑制剂阻断有抗性的长期存在的肿瘤。在此，我们表明，静脉内注射活的或瘤内注射热灭活（HK）的鼠伤寒沙门氏菌，即使不产生活肿瘤抗原，也能与过继性T细胞疗法协同作用以根除肿瘤。这些数据表明，过继性T细胞转移与注射活的或死的鼠伤寒沙门氏菌相结合是一种很有前景的癌症治疗方法。
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