Cauli Alberto, Piga Matteo, Floris Alberto, Mathieu Alessandro
Rheumatology Unit, Department of Medical Sciences, Policlinico of the University of Cagliari, Monserrato, Cagliari, Italy.
Immunotargets Ther. 2015 Oct 1;4:185-90. doi: 10.2147/ITT.S62870. eCollection 2015.
TH17 is a lymphocyte subset, which is characterized by its polarization to secrete interleukin (IL)-17. IL-23 is the pivotal mediator responsible for TH17 differentiation and the IL-23/IL-17 axis has been strongly implicated in the pathogenesis of several immune mediated diseases, in particular chronic arthritis and skin psoriasis. This review will summarize the basic immunology and the new monoclonal antibodies, which antagonize this pathway allowing a new therapeutic approach.
辅助性T细胞17(TH17)是一种淋巴细胞亚群,其特征在于极化分泌白细胞介素(IL)-17。白细胞介素-23(IL-23)是负责TH17分化的关键介质,并且IL-23/IL-17轴与几种免疫介导疾病的发病机制密切相关,特别是慢性关节炎和皮肤银屑病。本综述将总结基础免疫学以及拮抗该途径的新型单克隆抗体,从而提供一种新的治疗方法。