Vrooman Lisa A, Bartolomei Marisa S
Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Reprod Toxicol. 2017 Mar;68:72-84. doi: 10.1016/j.reprotox.2016.07.015. Epub 2016 Jul 26.
Millions of children have been born worldwide though assisted reproductive technologies (ART). Consistent with the Developmental Origins of Health and Disease hypothesis, there is concern that ART can induce adverse effects, especially because procedures coincide with epigenetic reprogramming events. Although the majority of studies investigating the effects of ART have focused on perinatal outcomes, more recent studies demonstrate that ART-conceived children may be at increased risk for postnatal effects. Here, we present the current epidemiological evidence that ART-conceived children have detectable differences in blood pressure, body composition, and glucose homeostasis. Similar effects are observed in the ART mouse model, which have no underlying infertility, suggesting that cardiometabolic effects are likely caused by ART procedures and not due to reasons related to infertility. We propose that the mouse system can, consequently, be used to adequately study, modify, and improve outcomes for ART children.
全球已有数百万儿童通过辅助生殖技术(ART)出生。与健康与疾病的发育起源假说一致,人们担心ART会引发不良影响,尤其是因为这些程序与表观遗传重编程事件同时发生。尽管大多数研究ART影响的研究都集中在围产期结局上,但最近的研究表明,通过ART受孕的儿童出生后出现不良影响的风险可能更高。在此,我们展示了当前的流行病学证据,即通过ART受孕的儿童在血压、身体成分和葡萄糖稳态方面存在可检测到的差异。在没有潜在不孕问题的ART小鼠模型中也观察到了类似的影响,这表明心脏代谢效应可能是由ART程序引起的,而不是与不孕相关的原因。因此,我们建议可以利用小鼠系统来充分研究、改善通过ART受孕儿童的结局。