Gumz Michelle L
Department of Medicine, Division of Nephrology, Hypertension and Renal Transplantation, University of Florida, Gainesville, FL, USA.
Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL, USA.
Exp Physiol. 2016 Aug 1;101(8):1025-9. doi: 10.1113/EP085781.
What is the topic of this review? This brief symposium report is focused on the molecular and physiological evidence that supports a key role for the circadian clock in the regulation of kidney function. What advances does it highlight? Progress in understanding the molecular mechanism of the kidney clock is reviewed here, including new results from global 'omics' studies and candidate gene approaches. The molecular kidney clock is a master regulator of gene expression that affects renal electrolyte and drug handling as well as blood pressure. In this brief review, an overview of the molecular and physiological evidence for the kidney clock and the implications for the regulation of renal physiology and pathophysiology are presented. Accumulating evidence suggests that the molecular circadian clock acts as a master regulator of gene expression in the kidney. Global transcriptomic approaches have revealed the important finding that there are thousands of genes in the kidney subject to regulation by the molecular clock. Candidate gene approaches have also yielded information regarding regulation of renal sodium transport genes by the molecular clock. To date, the evidence linking the molecular kidney clock to rhythmic renal function provides strong support for the concept that circadian control of gene expression underlies rhythms in physiological function.
本综述的主题是什么？这篇简短的研讨会报告聚焦于支持生物钟在肾功能调节中起关键作用的分子和生理学证据。它突出了哪些进展？本文回顾了在理解肾脏生物钟分子机制方面取得的进展，包括来自全球“组学”研究和候选基因方法的新结果。分子肾脏生物钟是基因表达的主要调节因子，影响肾脏电解质和药物处理以及血压。在这篇简短的综述中，概述了肾脏生物钟的分子和生理学证据以及对肾脏生理学和病理生理学调节的影响。越来越多的证据表明，分子生物钟在肾脏中作为基因表达的主要调节因子发挥作用。全球转录组学方法揭示了一个重要发现，即肾脏中有数千个基因受分子生物钟调控。候选基因方法也产生了有关分子生物钟对肾脏钠转运基因调控的信息。迄今为止，将分子肾脏生物钟与有节律的肾功能联系起来的证据，为基因表达的昼夜节律控制是生理功能节律基础这一概念提供了有力支持。
