Solocinski Kristen, Gumz Michelle L
Department of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida, Gainesville, FloridaDepartment of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida.
Department of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida, Gainesville, FloridaDepartment of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida
J Biol Rhythms. 2015 Dec;30(6):470-86. doi: 10.1177/0748730415610879. Epub 2015 Nov 2.
Since the kidney is integral to maintenance of fluid and ion homeostasis, and therefore blood pressure regulation, its proper function is paramount. Circadian fluctuations in blood pressure, renal blood flow, glomerular filtration rate, and sodium and water excretion have been documented for decades, if not longer. Recent studies on the role of circadian clock proteins in the regulation of a variety of renal transport genes suggest that the molecular clock in the kidney controls circadian fluctuations in renal function. The circadian clock appears to be a critical regulator of renal function with important implications for the treatment of renal pathologies, which include chronic kidney disease and hypertension. The development, regulation, and mechanism of the kidney clock are reviewed here.
由于肾脏对于维持体液和离子平衡以及血压调节至关重要，因此其正常功能至关重要。血压、肾血流量、肾小球滤过率以及钠和水排泄的昼夜节律波动已有数十年的记录，甚至更长时间。最近关于生物钟蛋白在多种肾脏转运基因调节中作用的研究表明，肾脏中的分子时钟控制着肾功能的昼夜节律波动。生物钟似乎是肾功能的关键调节因子，对包括慢性肾病和高血压在内的肾脏疾病的治疗具有重要意义。本文综述了肾脏生物钟的发育、调节及其机制。
