Department of Chemistry and Center of Excellence in Biomaterials, Faculty of Science, Naresuan University, Phitsanulok 65000 Thailand.
Department of Chemistry and Center of Excellence in Biomaterials, Faculty of Science, Naresuan University, Phitsanulok 65000 Thailand.
Carbohydr Polym. 2016 Oct 20;151:251-259. doi: 10.1016/j.carbpol.2016.05.081. Epub 2016 May 24.
Multi-responsive composite microspheres were synthesized via an in situ free radical polymerization of thermo-responsive poly(N-isopropylacrylamide) (poly(NIPAAm)) in the presence of carboxymethylchitosan (CMC) and magnetite nanoparticles (MNPs) followed by glutaraldehyde crosslinking. Formulation conditions of the composite microspheres were tuned such that spherical microspheres with narrow size distributions were obtained (30.0±1.0μm in diameter). They responded well to an applied magnetic field and showed water swelling responses to the change in solution pH and temperature. The release of an entrapped indomethacin model drug was accelerated when the solution temperature was above its lower critical solution temperature (LCST) (50°C) or when the solution pH was in basic conditions (pH 11). These responsive properties can be used as triggering mechanisms for releases of the entrapped drugs from the microspheres, indicating their great potentials for use in controlled release applications.
通过在羧甲基壳聚糖（CMC）和磁铁矿纳米粒子（MNPs）存在的情况下，原位自由基聚合温敏性聚（N-异丙基丙烯酰胺）（poly（NIPAAm）），合成了多响应性复合微球，然后进行戊二醛交联。通过调整复合微球的配方条件，获得了具有较窄粒径分布的球形微球（直径为 30.0±1.0μm）。它们对施加的磁场有很好的响应，并表现出对溶液 pH 值和温度变化的水膨胀响应。当溶液温度高于其低临界溶液温度（LCST）（50°C）或溶液 pH 值处于碱性条件（pH 11）时，包封的吲哚美辛模型药物的释放速度加快。这些响应性能可用作从微球中释放包封药物的触发机制，表明它们在控制释放应用中具有很大的潜力。
