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德国慢性阻塞性肺疾病(COPD)患者远程监测干预措施的成本效益分析。

Cost-Utility Analysis of Telemonitoring Interventions for Patients with Chronic Obstructive Pulmonary Disease (COPD) in Germany.

作者信息

Hofer Florian, Achelrod Dmitrij, Stargardt Tom

机构信息

Hamburg Center for Health Economics (HCHE), Universität Hamburg, Esplanade 36, 20354, Hamburg, Germany.

出版信息

Appl Health Econ Health Policy. 2016 Dec;14(6):691-701. doi: 10.1007/s40258-016-0267-9.

Abstract

BACKGROUND

Chronic obstructive pulmonary disease (COPD) poses major challenges for health care systems. Previous studies suggest that telemonitoring could be effective in preventing hospitalisations and hence reduce costs.

OBJECTIVE

The aim was to evaluate whether telemonitoring interventions for COPD are cost-effective from the perspective of German statutory sickness funds.

METHODS

A cost-utility analysis was conducted using a combination of a Markov model and a decision tree. Telemonitoring as add-on to standard treatment was compared with standard treatment alone. The model consisted of four transition stages to account for COPD severity, and a terminal stage for death. Within each cycle, the frequency of exacerbations as well as outcomes for 2015 costs and quality adjusted life years (QALYs) for each stage were calculated. Values for input parameters were taken from the literature. Deterministic and probabilistic sensitivity analyses were conducted.

RESULTS

In the base case, telemonitoring led to an increase in incremental costs (€866 per patient) but also in incremental QALYs (0.05 per patient). The incremental cost-effectiveness ratio (ICER) was thus €17,410 per QALY gained. A deterministic sensitivity analysis showed that hospitalisation rate and costs for telemonitoring equipment greatly affected results. The probabilistic ICER averaged €34,432 per QALY (95 % confidence interval 12,161-56,703).

CONCLUSION

We provide evidence that telemonitoring may be cost-effective in Germany from a payer's point of view. This holds even after deterministic and probabilistic sensitivity analyses.

摘要

背景

慢性阻塞性肺疾病(COPD)给医疗保健系统带来了重大挑战。先前的研究表明,远程监测在预防住院方面可能有效,从而降低成本。

目的

从德国法定疾病基金的角度评估COPD远程监测干预措施是否具有成本效益。

方法

采用马尔可夫模型和决策树相结合的方法进行成本效用分析。将作为标准治疗附加措施的远程监测与单独的标准治疗进行比较。该模型包括四个用于考虑COPD严重程度的过渡阶段和一个死亡终末阶段。在每个周期内,计算每个阶段的急性加重频率以及2015年成本和质量调整生命年(QALY)的结果。输入参数的值取自文献。进行了确定性和概率敏感性分析。

结果

在基础案例中,远程监测导致增量成本增加(每位患者866欧元),但也导致增量QALY增加(每位患者0.05)。因此,每获得一个QALY的增量成本效益比(ICER)为17,410欧元。确定性敏感性分析表明,住院率和远程监测设备成本对结果有很大影响。概率ICER平均为每QALY 34,432欧元(95%置信区间12,161 - 56,703)。

结论

我们提供的证据表明,从支付方的角度来看,远程监测在德国可能具有成本效益。即使经过确定性和概率敏感性分析,情况依然如此。

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