Takeuchi M, Funahashi H, Sato Y, Imai T, Nozaki H, Mizuno S, Takagi H
Second Department of Surgery, Nagoya University School of Medicine, Japan.
Nihon Geka Gakkai Zasshi. 1989 Feb;90(2):273-9.
Total removal and subsequent autotransplantation of parathyroid glands were carried out in operations for thyroid carcinoma in 25 cases. For the purpose of fine dissection of paratracheal lymph nodes, before thyroidectomy more than 2 parathyroid glands were found and transplanted into greater pectoralis muscle. The patients who underwent surgery were studied for more than one year following operation to determine the short term and long term outcomes of the procedure. None of the patients received prophylactic calcium supplement therapy except for hypocalcemic symptoms. In thirteen patients, the parathyroid function was almost completely restored within 3 weeks without any postoperative substitution therapy, with an obvious surge in the plasma PTH level on 5P.O.D. The serum Ca level started to elevate on 7P.O.D. and recovered to 97.4% of the preoperative value 3 weeks after transplantation. As for the 12 patients who exhibited hypocalcemic symptoms, Ca lactate and hydroxycholecalciferol were administered for only 24.7 and 17.0 days, respectively. Serum levels of Ca and P, as well as the index of bone mineral content, were all within the extremely excellent range even one year after operation. None of the patients was on a substitution regimen. These results suggest that autotransplantation is a valuable alternative for the preservation of the parathyroid function in operations for thyroid carcinoma.
在25例甲状腺癌手术中进行了甲状旁腺全切及后续自体移植。为了精细解剖气管旁淋巴结,在甲状腺切除术前发现2个以上甲状旁腺并将其移植到胸大肌中。对接受手术的患者术后进行了一年多的研究,以确定该手术的短期和长期效果。除有低钙血症症状外,无一例患者接受预防性补钙治疗。13例患者在术后3周内甲状旁腺功能几乎完全恢复,无需任何术后替代治疗,术后第5天血浆甲状旁腺激素水平明显升高。术后第7天血清钙水平开始升高,移植后3周恢复到术前值的97.4%。对于12例出现低钙血症症状的患者,乳酸钙和骨化醇的给药时间分别仅为24.7天和17.0天。即使在术后一年,患者的血清钙和磷水平以及骨矿物质含量指标均处于极佳范围。无一例患者接受替代治疗方案。这些结果表明,自体移植是甲状腺癌手术中保留甲状旁腺功能的一种有价值的替代方法。