用于肾上腺靶向的内分泌特异性近红外荧光团。
Endocrine-specific NIR fluorophores for adrenal gland targeting.
作者信息
Ashitate Yoshitomo, Levitz Andrew, Park Min Ho, Hyun Hoon, Venugopal Vivek, Park GwangLi, El Fakhri Georges, Henary Maged, Gioux Sylvain, Frangioni John V, Choi Hak Soo
机构信息
Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA and Department of Gastroenterological Surgery II, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan.
Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA.
出版信息
Chem Commun (Camb). 2016 Aug 11;52(67):10305-8. doi: 10.1039/c6cc03845j.
Abstract
The adrenal glands (AGs) are relatively small yet require definitive identification during their resection, or more commonly their avoidance. To enable image-guided surgery involving the AGs, we have developed novel near-infrared (NIR) fluorophores that target the AGs after a single intravenous injection, which provided dual-NIR image-guided resection or avoidance of the AGs during both open and minimally-invasive surgery.
摘要
肾上腺（AGs）相对较小，但在切除过程中需要明确识别，或者更常见的是避免切除。为了实现涉及肾上腺的图像引导手术，我们开发了新型近红外（NIR）荧光团，单次静脉注射后可靶向肾上腺，在开放手术和微创手术中均可实现双近红外图像引导的肾上腺切除或避开肾上腺。
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