Mórocz I, Barna T, Mándi A, Szepesi K, Gomba S
Morphol Igazsagugyi Orv Sz. 1989 Apr;29(2):124-33.
Of malignancies occurring in bones, metastatic tumours are the most frequent. Due to the increase of mean life span and to other factors the incidence of tumours is growing. Nevertheless, survival chances of patients suffering from tumours are also improving due to advance in diagnostics and to the application of complex therapy. These trends have substantially increased the number of recognized and manageable bone metastases. In general, life expectations of a tumour-patient are determined by the metastases therefore, the question of diagnostics and management of bone metastases is worth of special attention. Authors have performed a clinicopathological survey of patients of the past eight years who have suffered fracture due to bone metastases and were treated surgically. In one-third of the patients the primary tumour was unknown at the time of the fracture. On the basis of the histological pattern the detection of the parent-organ, particularly in adenocarcinomas, was not possible. Independently from the radiological appearance of the metastasis simultaneous osteogenesis and osteolysis were histologically observed.
在发生于骨骼的恶性肿瘤中，转移性肿瘤最为常见。由于平均寿命的延长以及其他因素，肿瘤的发病率正在上升。然而，由于诊断技术的进步和综合治疗的应用，肿瘤患者的生存几率也在提高。这些趋势显著增加了已被识别和可处理的骨转移瘤的数量。一般来说，肿瘤患者的预期寿命由转移瘤决定，因此，骨转移瘤的诊断和治疗问题值得特别关注。作者对过去八年因骨转移瘤骨折并接受手术治疗的患者进行了临床病理调查。在三分之一的患者中，骨折时原发肿瘤不明。基于组织学模式，无法检测到原发器官，尤其是在腺癌中。与转移瘤的放射学表现无关，组织学观察到同时存在成骨和溶骨现象。
