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线粒体脑肌病伴乳酸血症和卒中样发作(MELAS)的影像学表现

Imaging of MELAS.

作者信息

Malhotra Konark, Liebeskind David S

机构信息

Department of Neurology, Vascular Neurology Fellow, UCLA, Los Angeles, CA, USA.

Neurovascular Imaging Research Core, Neuroscience Research Building, 635 Charles E Young Drive South, Suite 225, Los Angeles, CA, 90095-7334, USA.

出版信息

Curr Pain Headache Rep. 2016 Sep;20(9):54. doi: 10.1007/s11916-016-0583-7.

DOI:10.1007/s11916-016-0583-7
PMID:27477183
Abstract

Mitochondrial diseases are multisystem disorders that frequently involve the central nervous system. The clinical presentation of these disorders may be challenging to differentiate from cerebrovascular disorders. Various imaging techniques are now available that provide a wide range of imaging modalities during initial clinical evaluation and throughout the disease course. Recent technological advancements have introduced advanced neuroimaging modalities that provide detailed information of metabolic disorders at the tissue level. Imaging findings, though diverse, usually have characteristic features that support differentiating these disorders from vascular syndromes. This article provides an overview of various neuroimaging modalities available along with the advent of new imaging techniques being utilized in these disorders.

摘要

线粒体疾病是多系统疾病,常累及中枢神经系统。这些疾病的临床表现可能难以与脑血管疾病相鉴别。现在有多种成像技术可供使用,在初始临床评估期间及整个病程中提供广泛的成像方式。最近的技术进步引入了先进的神经成像方式,可在组织水平提供代谢紊乱的详细信息。成像结果虽然多样,但通常具有支持将这些疾病与血管综合征相鉴别的特征。本文概述了各种可用的神经成像方式以及在这些疾病中使用的新成像技术的出现情况。

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本文引用的文献

1
Imaging in Endovascular Stroke Trials.血管内卒中试验中的影像学检查
J Neuroimaging. 2015 Jul-Aug;25(4):517-27. doi: 10.1111/jon.12272.
2
Progress in Diagnosing Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-like Episodes.线粒体肌病、脑病、乳酸酸中毒和卒中样发作的诊断进展
Chin Med J (Engl). 2015 Jul 5;128(13):1820-5. doi: 10.4103/0366-6999.159360.
3
MR OEF imaging in MELAS.线粒体脑肌病伴乳酸血症和卒中样发作(MELAS)中的磁共振波谱成像(MRS)脑氧提取分数(OEF)成像
Radiol Case Rep. 2024 Sep 25;19(12):6347-6353. doi: 10.1016/j.radcr.2024.08.159. eCollection 2024 Dec.
4
Clinical Reasoning: A 17-Year-Old Girl With Progressive Cognitive Impairment.临床推理:一名 17 岁认知功能进行性减退的女孩
Neurology. 2023 Oct 3;101(14):e1466-e1472. doi: 10.1212/WNL.0000000000207597. Epub 2023 Jul 25.
5
The Structure and Organizations of ICHD-3 Differential Diagnoses through DiffNet: A Pilot Study.通过DiffNet对国际头痛疾病分类第三版(ICHD-3)鉴别诊断的结构与组织:一项初步研究
Diagnostics (Basel). 2022 Oct 25;12(11):2589. doi: 10.3390/diagnostics12112589.
6
MRI Features of Stroke-Like Episodes in Mitochondrial Encephalomyopathy With Lactic Acidosis and Stroke-Like Episodes.伴乳酸性酸中毒和卒中样发作的线粒体脑肌病中卒中样发作的MRI特征
Front Neurol. 2022 Feb 9;13:843386. doi: 10.3389/fneur.2022.843386. eCollection 2022.
7
Adult-onset mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS) syndrome with progressive sensorineural hearing loss: A case report.成人起病的线粒体脑肌病伴乳酸血症和卒中样发作(MELAS)综合征合并进行性感音神经性听力损失:一例报告。
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8
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Neuroimage Clin. 2020;28:102480. doi: 10.1016/j.nicl.2020.102480. Epub 2020 Oct 27.
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Cureus. 2020 Apr 27;12(4):e7862. doi: 10.7759/cureus.7862.
Methods Enzymol. 2014;547:433-44. doi: 10.1016/B978-0-12-801415-8.00021-7.
4
Headache and acute stroke.头痛与急性中风。
Curr Pain Headache Rep. 2014 Sep;18(9):444. doi: 10.1007/s11916-014-0444-1.
5
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Neurology. 2014 Mar 4;82(9):798-805. doi: 10.1212/WNL.0000000000000169. Epub 2014 Jan 29.
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J Neurol Neurosurg Psychiatry. 2014 Sep;85(9):1055-6. doi: 10.1136/jnnp-2013-306933. Epub 2013 Dec 2.
8
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9
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10
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