Bhatta Anil Kumar, Keyal Uma, Wang Xiu Li
Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China.
Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China.
Photodiagnosis Photodyn Ther. 2016 Sep;15:228-35. doi: 10.1016/j.pdpdt.2016.07.010. Epub 2016 Jul 28.
Other than a cosmetic concern, Onychomycosis is also a prevalent nail disease, which is extremely difficult to treat, and sometimes is refractory to conventional therapy. Moreover, many patients are not eligible to take oral antifungals owing to polypharmacy and comorbidities. Systemic side effects seen with oral antifungals have lead to patient nonadherence and adverse events. Therefore, newer therapies are being investigated for onychomycosis that would be free of systemic complications posed by oral therapy. Photodynamic therapy (PDT) is one of those being currently studied, which involves the use of photosensitizer and a light source to excite the photosensitizer to generate reactive oxygen species. The present review will put some light on PDT as an upcoming treatment modality for onychomycosis. We performed a systematic review of the literature to find the articles relevant to the use of PDT for onychomycosis. From the primary search of 43 articles, 17 papers are included in this review.
除了美观问题外，甲癣也是一种常见的指甲疾病，极难治疗，有时对传统疗法也有抗药性。此外，由于多种药物联合使用和合并症，许多患者没有资格口服抗真菌药物。口服抗真菌药物出现的全身副作用导致患者不依从治疗并引发不良事件。因此，正在研究针对甲癣的新疗法，这些疗法不会产生口服治疗引起的全身性并发症。光动力疗法（PDT）是目前正在研究的疗法之一，它涉及使用光敏剂和光源来激发光敏剂产生活性氧。本综述将阐述光动力疗法作为一种即将用于治疗甲癣的方法。我们对文献进行了系统综述，以查找与光动力疗法治疗甲癣相关的文章。在对43篇文章进行初步检索后，本综述纳入了17篇论文。
