甲状腺功能亢进改善非酒精性脂肪性肝炎的病理状况：1例合并格雷夫斯病的非酒精性脂肪性肝炎病例
Hyperthyroidism Improves the Pathological Condition of Nonalcoholic Steatohepatitis: A Case of Nonalcoholic Steatohepatitis with Graves' Disease.
作者信息
Miyake Teruki, Matsuura Bunzo, Furukawa Shinya, Todo Yasuhiko, Yamamoto Shin, Yoshida Osamu, Imai Yusuke, Watanabe Takao, Yamamoto Yasunori, Hirooka Masashi, Tokumoto Yoshio, Kumagi Teru, Abe Masanori, Seike Hirotaka, Miyauchi Shozo, Hiasa Yoichi
机构信息
Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Japan.
出版信息
Intern Med. 2016;55(15):2019-23. doi: 10.2169/internalmedicine.55.6640. Epub 2016 Aug 1.
3,5,3'-triiodo-L-thyronine regulates the glucose metabolism, lipid metabolism, and hepatic steatosis. Several groups have shown the relationships between hypothyroidism and nonalcoholic fatty liver and hypothyroidism and nonalcoholic steatohepatitis (NASH). However, the effect of hyperthyroidism on NASH has not yet been investigated. We herein report effects of thyroid hormone on the pathological condition of NASH in a patient with NASH complicated by Graves' disease. In our case, the liver enzyme level improved with the increasing thyroid hormone level; however, the liver enzyme level was aggravated with the improving thyroid hormone level. Therefore, hyperthyroidism may improve the pathological condition of NASH.
3,5,3'-三碘-L-甲状腺原氨酸调节葡萄糖代谢、脂质代谢和肝脂肪变性。多个研究小组已表明甲状腺功能减退与非酒精性脂肪肝以及甲状腺功能减退与非酒精性脂肪性肝炎（NASH）之间的关系。然而，甲状腺功能亢进对NASH的影响尚未得到研究。我们在此报告了甲状腺激素对一名合并格雷夫斯病的NASH患者NASH病理状况的影响。在我们的病例中，肝酶水平随着甲状腺激素水平的升高而改善；然而，肝酶水平随着甲状腺激素水平的改善而加重。因此，甲状腺功能亢进可能改善NASH的病理状况。
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