Rose Brandon J, Kooyman David L
Department of Physiology and Developmental Biology, Brigham Young University (BYU), LSB 4005, Provo, UT 84602, USA.
Dis Markers. 2016;2016:4895050. doi: 10.1155/2016/4895050. Epub 2016 Jul 13.
Matrix metalloproteinases are a class of enzymes involved in the degradation of extracellular matrix molecules. While these molecules are exceptionally effective mediators of physiological tissue remodeling, as occurs in wound healing and during embryonic development, pathological upregulation has been implicated in many disease processes. As effectors and indicators of pathological states, matrix metalloproteinases are excellent candidates in the diagnosis and assessment of these diseases. The purpose of this review is to discuss matrix metalloproteinases as they pertain to cartilage health, both under physiological circumstances and in the instances of osteoarthritis and rheumatoid arthritis, and to discuss their utility as biomarkers in instances of the latter.
基质金属蛋白酶是一类参与细胞外基质分子降解的酶。虽然这些分子在生理组织重塑过程中，如伤口愈合和胚胎发育期间，是非常有效的介质，但病理上调与许多疾病过程有关。作为病理状态的效应物和指标，基质金属蛋白酶是这些疾病诊断和评估的优秀候选者。本综述的目的是讨论基质金属蛋白酶在生理情况下以及骨关节炎和类风湿关节炎情况下与软骨健康的关系，并讨论它们在后一种情况下作为生物标志物的效用。
