Vulic Dusko, Loncar Sasa, Ostojic Miodrag, Marinkovic Jelena, Vulic Branka, Wong Nathan D
Department of Internal Medicine, School of Medicine, University of Banja Luka, Republic of Srpska, Bosnia and Herzegovina.
Department of Cardiology, Clinical Center Banja Luka, Republic of Srpska, Bosnia and Herzegovina.
Arch Med Sci. 2016 Aug 1;12(4):736-41. doi: 10.5114/aoms.2016.60958. Epub 2016 Jul 1.
Risk factor differences among offspring of patients with premature coronary heart disease (CHD) have not been widely studiem.
We examined 161 persons from the region of Banja Luka, including 81 children (mean age: 25.9 years, 45.7% female) with a history of CHD and a control group of 80 persons (mean age: 24.1, 50% female). Medical history interviews and risk factor measurements were performed.
There were differences in mean body amss index (BMI) (26.1 kg/m(2) vs. 23.1 kg/m(2), p < 0.0001), waist circumference (87.7 cm vs. 83.9 cm, p = 0.002), hip circumference (99.3 cm vs. 95.84 cm, p < 0.002), systolic blood pressure (BP) (128.09 mm Hg vs. 122.7 mm Hg, p = 0.007), and diastolic BP (99.3 mm Hg vs. 95.8 mm Hg, p = 0.07). Moreover, HDL-cholesterol was significantly lower (1.1 mmol/l vs. 1.4 mmol/l, p = 0.0001), triglycerides significantly higher (2.2 mmol/l vs. 1.6 mmol/l, p = 0.001), and TC/HDL-ratio was significantly higher (5.1 vs. 4.0, p < 0.001) comparing cases and controls, respectively, adjusted for age, gender, and standard CHD risk factors total cholesterol, LDL and HDL cholesterol, smoking, systolic and diastolic BP, and BMI, those with HDL-C > 1.0 mmol/l in men and 1.2 mmol/l in women had a reduced odds (OR = 0.08, 95% CI: 0.02-0.34 of CHD as well as those with change of fat type (OR = 0.26, 95% CI: 0.11-0.60).
Children of parents with premature CHD have a significantly greater burden of CHD risk factors, with low HDL-C, in particular, being associated with an increased likelihood of being a child of a parent with premature CHD.
早发性冠心病（CHD）患者后代的危险因素差异尚未得到广泛研究。
我们对巴尼亚卢卡地区的161人进行了检查，其中包括81名有冠心病病史的儿童（平均年龄：25.9岁，45.7%为女性）和80人的对照组（平均年龄：24.1岁，50%为女性）。进行了病史访谈和危险因素测量。
平均体重指数（BMI）存在差异（26.1kg/m²对23.1kg/m²，p<0.0001）、腰围（87.7cm对83.9cm，p = 0.002）、臀围（99.3cm对95.84cm，p<0.002）、收缩压（BP）（128.09mmHg对122.7mmHg，p = 0.007）和舒张压（99.3mmHg对95.8mmHg，p = 0.07）。此外，高密度脂蛋白胆固醇显著降低（1.1mmol/l对1.4mmol/l，p = 0.0001），甘油三酯显著升高（2.2mmol/l对1.6mmol/l，p = 0.001），病例组与对照组相比，总胆固醇/高密度脂蛋白比值显著升高（5.1对4.0，p<0.001）。在对年龄、性别和标准冠心病危险因素（总胆固醇、低密度脂蛋白和高密度脂蛋白胆固醇、吸烟、收缩压和舒张压以及BMI）进行调整后，男性高密度脂蛋白胆固醇>1.0mmol/l且女性>1.2mmol/l的人群患冠心病的几率降低（OR = 0.08，95%可信区间：0.02 - 0.34），脂肪类型改变的人群也是如此（OR = 0.26，95%可信区间：0.11 - 0.60）。
早发性冠心病患者的子女患冠心病危险因素的负担明显更大，尤其是低高密度脂蛋白胆固醇与早发性冠心病患者子女的患病可能性增加有关。
