Pietrzak Aldona, Chabros Paweł, Grywalska Ewelina, Kiciński Paweł, Pietrzak-Franciszkiewicz Kinga, Krasowska Dorota, Kandzierski Grzegorz
Department of Dermatology, Venereology and Pediatric Dermatology, Medical University of Lublin, Lublin, Poland.
Orthopedics and Traumatology Department, Medical University of Lublin, Lublin, Poland.
Arch Med Sci. 2019 Mar;15(2):369-375. doi: 10.5114/aoms.2018.74021. Epub 2018 Mar 8.
Psoriasis and psoriatic arthritis (PSA) are chronic, inflammatory, systemic diseases characterized by metabolic abnormalities, including an increased cardiovascular risk and an oxidative imbalance. This study assessed blood parameters of lipid metabolism and markers of oxidative stress in patients with psoriasis and PSA.
The study included 93 patients with psoriasis (31 patients with PSA and psoriasis, 62 patients with psoriasis vulgaris), and 60 healthy, age-matched controls. Serum concentrations of the glucose and the following lipid metabolism parameters were measured: triglycerides (TG), total cholesterol (TC), low-density lipoproteins (LDL), very low-density lipoproteins (VLDL), high-density lipoproteins (HDL), and apolipoproteins A and B (ApoA, ApoB). Oxidative status was determined as serum concentrations of ox-LDL/MDA Adduct. The Psoriasis Area and Severity Index (PASI) was used to determine disease severity.
Among the three studied groups, controls had the highest HDL concentration ( < 0.001), patients with PSA had the highest ApoB concentration ( < 0.05), ApoA : ApoB ratio ( < 0.05), ox-LDL/MDA adduct concentration ( < 0.001), and TC: HDL and LDL : HDL ratios (accordingly < 0.05, < 0.01). In patients with psoriasis or PSA, oxidative status correlated positively with TC and ApoB concentrations.
In line with previous research, among patients with psoriasis and PSA, we found lipid metabolism abnormalities and an oxidative imbalance, which might be due to chronic inflammation in these conditions. Effective treatment of patients with psoriasis or PSA could reduce the risk of cardiovascular diseases.
银屑病和银屑病关节炎（PSA）是慢性炎症性全身性疾病，其特征为代谢异常，包括心血管风险增加和氧化失衡。本研究评估了银屑病和PSA患者的脂质代谢血液参数及氧化应激标志物。
本研究纳入93例银屑病患者（31例PSA合并银屑病患者，62例寻常型银屑病患者）以及60例年龄匹配的健康对照。测量血清葡萄糖浓度及以下脂质代谢参数：甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白（LDL）、极低密度脂蛋白（VLDL）、高密度脂蛋白（HDL）以及载脂蛋白A和B（ApoA、ApoB）。氧化状态通过血清氧化型低密度脂蛋白/丙二醛加合物浓度测定。采用银屑病面积和严重程度指数（PASI）来确定疾病严重程度。
在三个研究组中，对照组的HDL浓度最高（<0.001），PSA患者的ApoB浓度最高（<0.05）、ApoA:ApoB比值最高（<0.05）、氧化型低密度脂蛋白/丙二醛加合物浓度最高（<0.001），以及TC:HDL和LDL:HDL比值最高（分别为<0.05、<0.01）。在银屑病或PSA患者中，氧化状态与TC和ApoB浓度呈正相关。
与先前研究一致，在银屑病和PSA患者中，我们发现了脂质代谢异常和氧化失衡，这可能是由于这些病症中的慢性炎症所致。对银屑病或PSA患者进行有效治疗可降低心血管疾病风险。
