Nemcsik János, László Andrea, Lénárt Lilla, Eörsi Dániel, Torzsa Péter, Kőrösi Beáta, Cseprekál Orsolya, Tislér András, Tabák Ádám, Gonda Xenia, Rihmer Zoltán, Hodrea Judit, Nemcsik-Bencze Zsófia, Fekete Andrea
Department of Family Medicine, Semmelweis University Budapest, Budapest, Hungary.
Health Service of Zugló (ZESZ), Budapest, Hungary.
Ann Gen Psychiatry. 2016 Jul 29;15:17. doi: 10.1186/s12991-016-0104-4. eCollection 2016.
Brain-derived neurotrophic factor (BDNF) has neuroprotective, proangiogenic and myogenic effects and, therefore, possibly acts as a psychosomatic mediator. Here, we measured serum BDNF (seBDNF) level in hypertensive patients (HT) and healthy controls (CONT) and its relation to affective temperaments, depression and anxiety scales, and arterial stiffness parameters.
In this cross-sectional study, affective temperaments, anxiety, and depression were studied with questionnaires (TEMPS-A, HAM-A, and BDI, respectively). SeBDNF level and routine laboratory parameters were measured as well. Arterial stiffness was evaluated with a tonometric method.
Allover, 151 HT, and 32 CONT subjects were involved in the study. SeBDNF level was significantly higher in HT compared to CONT (24880 ± 8279 vs 21202.6 ± 6045.5 pg/mL, p < 0.05). In the final model of regression analysis, hyperthymic temperament score (Beta = 405.8, p = 0.004) and the presence of hypertension (Beta = 6121.2, p = 0.001) were independent determinants of seBDNF. In interaction analysis, it was found that in HT, a unit increase in hyperthymic score was associated with a 533.3 (95 %CI 241.3-825.3) pg/mL higher seBDNF. This interaction was missing in CONT.
Our results suggest a complex psychosomatic involvement of BDNF in the pathophysiology of hypertension, where hyperthymic affective temperament may have a protective role. BDNF is not likely to have an effect on large arteries.
脑源性神经营养因子（BDNF）具有神经保护、促血管生成和生肌作用，因此可能作为一种心身调节因子发挥作用。在此，我们测量了高血压患者（HT）和健康对照者（CONT）的血清BDNF（seBDNF）水平及其与情感气质、抑郁和焦虑量表以及动脉僵硬度参数的关系。
在这项横断面研究中，分别使用问卷（分别为TEMPS-A、HAM-A和BDI）对情感气质、焦虑和抑郁进行研究。同时测量了seBDNF水平和常规实验室参数。采用张力测量法评估动脉僵硬度。
总共151名HT患者和32名CONT受试者参与了研究。与CONT相比，HT患者的seBDNF水平显著更高（24880±8279 vs 21202.6±6045.5 pg/mL，p<0.05）。在回归分析的最终模型中，兴奋性气质得分（β=405.8，p=0.004）和高血压的存在（β=6121.2，p=0.001）是seBDNF的独立决定因素。在交互分析中，发现在HT患者中，兴奋性得分每增加一个单位，seBDNF就会升高533.3（95%CI 241.3-825.3）pg/mL。CONT中不存在这种交互作用。
我们研究结果提示BDNF在心身方面复杂地参与了高血压的病理生理过程，其中兴奋性情感气质可能具有保护作用。BDNF不太可能对大动脉产生影响。
