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用于皮层应用的刺激装置在时域中的建模与仿真

Modeling and Simulations in Time Domain of a Stimulation Set-up for Cortical Applications.

作者信息

Schweigmann Michael, Kirchhoff Frank, Koch Klaus P

机构信息

Department of Electrical Engineering, Trier University of applied Sciences, Trier, Germany; Department of Molecular Physiology, School of Medicine, University of Saarland, Homburg, Germany.

Department of Molecular Physiology, School of Medicine, University of Saarland , Homburg, Germany.

出版信息

Eur J Transl Myol. 2016 Jun 13;26(2):6017. doi: 10.4081/ejtm.2016.6017.

Abstract

Electrical stimulation is used for example to treat neuronal disorders and depression with deep brain stimulation or transcranial electrical stimulation. Depending on the application, different electrodes are used and thus different electrical characteristics exist, which have to be handled by the stimulator. Without a measuring device the user would have to rely on the stimulator being able to deliver the needed stimulation signal. Therefore, the objective of this paper is to present a method to increase the level of confidence with characterization and modelling of the electrical behavior by using the example of one channel of our stimulation device for experimental use. In several simulation studies with an electrode model with values in a typical range for cortical applications the influence of the load onto the stimulator and the possibility to pre-estimate measuring signals in complex networks are shown.

摘要

例如,电刺激可通过深部脑刺激或经颅电刺激用于治疗神经元疾病和抑郁症。根据应用的不同,会使用不同的电极,因此存在不同的电学特性,刺激器必须对其进行处理。如果没有测量设备,用户将不得不依赖刺激器能够提供所需的刺激信号。因此,本文的目的是通过以我们用于实验的刺激设备的一个通道为例,提出一种通过对电行为进行表征和建模来提高置信度的方法。在几项使用电极模型进行的模拟研究中,该电极模型的值处于皮质应用的典型范围内,展示了负载对刺激器的影响以及在复杂网络中预先估计测量信号的可能性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6f9/4942707/656fcbe5ddf9/ejtm-2016-2-6017-g001.jpg

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