2009年至2012年期间，韩国京畿道儿童中A组轮状病毒G4P[6]毒株的高发病率。
High incidence of group A rotaviruses G4P[6] strains among children in Gyeonggi province of South Korea, from 2009 to 2012.
作者信息
Mun Su-Kyoung, Cho Han-Gil, Lee Hyun-Kyung, Park Sin-Hee, Park Po-Hyun, Yoon Mi-Hye, Jeong Hye-Sook, Lim Young-Hee
机构信息
Division of Public Health Research, Gyeonggi Province Institute of Health and Environment, Suwon, South Korea.
Division of Vaccine Research, Center for Infectious Diseases, National Institute of Health, Korea Centers for Disease Control & Prevention, Chungcheongbuk-do, South Korea.
出版信息
Infect Genet Evol. 2016 Oct;44:351-355. doi: 10.1016/j.meegid.2016.07.038. Epub 2016 Jul 30.
The genotype distribution of group A rotaviruses (RVAs) circulating in Gyeonggi province, South Korea between 2009 and 2012 was investigated. A total of 2619 stool specimens from sporadic acute gastroenteritis cases and 117 acute gastroenteritis outbreaks were analyzed. Among them, RVAs were detected from 263 (10.0%) sporadic cases and 3 (2.6%) outbreaks. The G4P[6] strains predominated (29.7%), followed by G1P[8] (19.4%), G2P[4] (15.6%), G3P[8] (13.3%) and G9P[8] (6.5%) strain. Especially 96.2% of the genotype G4P[6] strains were isolated from children<1year of age. Phylogenetic analysis revealed that genotype G4P[6] strains were members of sub-lineage Ie(G4) and Ia(P[6]). Intensified monitoring of RVAs, especially G4P[6] strains among young children, is essential to control RVA infections.
对2009年至2012年期间韩国京畿道地区流行的A组轮状病毒（RVA）的基因型分布进行了调查。共分析了来自散发性急性胃肠炎病例的2619份粪便标本和117起急性胃肠炎暴发事件。其中，在263例（10.0%）散发病例和3起（2.6%）暴发事件中检测到RVA。G4P[6]毒株占主导地位（29.7%），其次是G1P[8]（19.4%）、G2P[4]（15.6%）、G3P[8]（13.3%）和G9P[8]（6.5%）毒株。特别是96.2%的G4P[6]基因型毒株是从1岁以下儿童中分离出来的。系统发育分析表明，G4P[6]基因型毒株属于Ie（G4）和Ia（P[6]）亚分支。加强对RVA的监测，尤其是对幼儿中的G4P[6]毒株的监测，对于控制RVA感染至关重要。
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