体内研究的设计、分析与呈现的考量因素
Considerations for the design, analysis and presentation of in vivo studies.
作者信息
Ranstam J, Cook J A
机构信息
Mdas AB, Rotfruktsgatan 12B, SE-27154 Ystad, Sweden.
Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Botnar Research Centre Windmill Road, Oxford OX3 7LD, UK.
出版信息
Osteoarthritis Cartilage. 2017 Mar;25(3):364-368. doi: 10.1016/j.joca.2016.06.023. Epub 2016 Jul 30.
OBJECTIVE
To describe, explain and give practical suggestions regarding important principles and key methodological challenges in the study design, statistical analysis, and reporting of results from in vivo studies.
CONCLUSIONS
Pre-specifying endpoints and analysis, recognizing the common underlying assumption of statistically independent observations, performing sample size calculations, and addressing multiplicity issues are important parts of an in vivo study. A clear reporting of results and informative graphical presentations of data are other important parts.
目的
描述、解释并针对体内研究的设计、统计分析及结果报告中的重要原则和关键方法学挑战给出实用建议。
结论
预先确定终点和分析方法、认识到统计独立观察的共同潜在假设、进行样本量计算以及解决多重性问题是体内研究的重要组成部分。清晰地报告结果以及提供信息丰富的数据图形展示是其他重要部分。
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