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Time to be positive about negative data?

作者信息

Vincent T, Malfait A-M

机构信息

Arthritis Research UK Centre for OA Pathogenesis, Kennedy Institute of Rheumatology, University of Oxford, Roosevelt Drive, Oxford OX3 7FY, UK.

Department of Internal Medicine, Division of Rheumatology & Department of Biochemistry, Rush University Medical Center, 1611 W. Harrison St, Suite 510, Chicago, IL 60612, USA.

出版信息

Osteoarthritis Cartilage. 2017 Mar;25(3):351-353. doi: 10.1016/j.joca.2017.01.016.

DOI:10.1016/j.joca.2017.01.016
PMID:28224967
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6034630/
Abstract
摘要

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Conflicts of interest may bias research into sugary drinks and obesity.利益冲突可能会使关于含糖饮料与肥胖的研究产生偏差。
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Molecular and structural imaging in surgically induced murine osteoarthritis.手术诱导的小鼠骨关节炎的分子和结构影像学。
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IL-1 in osteoarthritis: time for a critical review of the literature.白细胞介素-1在骨关节炎中的作用：对相关文献进行批判性综述的时候了。
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本文引用的文献

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Role of the C-C chemokine receptor-2 in a murine model of injury-induced osteoarthritis.C-C趋化因子受体2在损伤诱导的小鼠骨关节炎模型中的作用
Osteoarthritis Cartilage. 2017 Jun;25(6):914-925. doi: 10.1016/j.joca.2016.11.004. Epub 2016 Nov 14.
2
Considerations for the design and execution of protocols for animal research and treatment to improve reproducibility and standardization: "DEPART well-prepared and ARRIVE safely".提高动物研究和治疗方案的可重复性和标准化的设计与实施考量：“充分准备出发，安全抵达”。
Osteoarthritis Cartilage. 2017 Mar;25(3):354-363. doi: 10.1016/j.joca.2016.10.016. Epub 2016 Nov 2.
3
CCL2 and CCR2 regulate pain-related behaviour and early gene expression in post-traumatic murine osteoarthritis but contribute little to chondropathy.CCL2和CCR2调节创伤后小鼠骨关节炎中与疼痛相关的行为和早期基因表达，但对软骨病的影响很小。
Osteoarthritis Cartilage. 2017 Mar;25(3):406-412. doi: 10.1016/j.joca.2016.10.008. Epub 2016 Oct 13.
4
Interleukin-1 is not involved in synovial inflammation and cartilage destruction in collagenase-induced osteoarthritis.白细胞介素-1不参与胶原酶诱导的骨关节炎中的滑膜炎症和软骨破坏。
Osteoarthritis Cartilage. 2017 Mar;25(3):385-396. doi: 10.1016/j.joca.2016.09.009. Epub 2016 Sep 18.
5
Considerations for the design, analysis and presentation of in vivo studies.体内研究的设计、分析与呈现的考量因素
Osteoarthritis Cartilage. 2017 Mar;25(3):364-368. doi: 10.1016/j.joca.2016.06.023. Epub 2016 Jul 30.
6
Upregulation of Atrogin-1/FBXO32 is not necessary for cartilage destruction in mouse models of osteoarthritis.在骨关节炎小鼠模型中，Atrogin-1/FBXO32的上调对于软骨破坏并非必需。
Osteoarthritis Cartilage. 2017 Mar;25(3):397-400. doi: 10.1016/j.joca.2016.07.008. Epub 2016 Jul 30.
7
Upregulation of lipocalin-2 (LCN2) in osteoarthritic cartilage is not necessary for cartilage destruction in mice.骨关节炎软骨中脂质运载蛋白-2（LCN2）的上调对于小鼠软骨破坏并非必要。
Osteoarthritis Cartilage. 2017 Mar;25(3):401-405. doi: 10.1016/j.joca.2016.07.009. Epub 2016 Jul 29.
8
ADAMTS-5 takes centre stage in new developments for aggrecanase inhibitors.ADAMTS-5在聚集蛋白聚糖酶抑制剂的新进展中占据核心地位。
Osteoarthritis Cartilage. 2015 Aug;23(8):1231-2. doi: 10.1016/j.joca.2015.05.023. Epub 2015 May 28.
9
Lack of a chondroprotective effect of cyclooxygenase 2 inhibition in a surgically induced model of osteoarthritis in mice.在小鼠手术诱导的骨关节炎模型中，环氧化酶2抑制缺乏软骨保护作用。
Arthritis Rheum. 2012 Jan;64(1):198-203. doi: 10.1002/art.33324.
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Double-knockout of ADAMTS-4 and ADAMTS-5 in mice results in physiologically normal animals and prevents the progression of osteoarthritis.在小鼠中对ADAMTS - 4和ADAMTS - 5进行双敲除可产生生理上正常的动物，并阻止骨关节炎的进展。
Arthritis Rheum. 2007 Nov;56(11):3670-4. doi: 10.1002/art.23027.