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Time to be positive about negative data?

作者信息

Vincent T, Malfait A-M

机构信息

Arthritis Research UK Centre for OA Pathogenesis, Kennedy Institute of Rheumatology, University of Oxford, Roosevelt Drive, Oxford OX3 7FY, UK.

Department of Internal Medicine, Division of Rheumatology & Department of Biochemistry, Rush University Medical Center, 1611 W. Harrison St, Suite 510, Chicago, IL 60612, USA.

出版信息

Osteoarthritis Cartilage. 2017 Mar;25(3):351-353. doi: 10.1016/j.joca.2017.01.016.

Abstract
摘要

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Role of the C-C chemokine receptor-2 in a murine model of injury-induced osteoarthritis.
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CCL2 and CCR2 regulate pain-related behaviour and early gene expression in post-traumatic murine osteoarthritis but contribute little to chondropathy.
Osteoarthritis Cartilage. 2017 Mar;25(3):406-412. doi: 10.1016/j.joca.2016.10.008. Epub 2016 Oct 13.
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Interleukin-1 is not involved in synovial inflammation and cartilage destruction in collagenase-induced osteoarthritis.
Osteoarthritis Cartilage. 2017 Mar;25(3):385-396. doi: 10.1016/j.joca.2016.09.009. Epub 2016 Sep 18.
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Considerations for the design, analysis and presentation of in vivo studies.
Osteoarthritis Cartilage. 2017 Mar;25(3):364-368. doi: 10.1016/j.joca.2016.06.023. Epub 2016 Jul 30.
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Upregulation of Atrogin-1/FBXO32 is not necessary for cartilage destruction in mouse models of osteoarthritis.
Osteoarthritis Cartilage. 2017 Mar;25(3):397-400. doi: 10.1016/j.joca.2016.07.008. Epub 2016 Jul 30.
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Upregulation of lipocalin-2 (LCN2) in osteoarthritic cartilage is not necessary for cartilage destruction in mice.
Osteoarthritis Cartilage. 2017 Mar;25(3):401-405. doi: 10.1016/j.joca.2016.07.009. Epub 2016 Jul 29.
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ADAMTS-5 takes centre stage in new developments for aggrecanase inhibitors.
Osteoarthritis Cartilage. 2015 Aug;23(8):1231-2. doi: 10.1016/j.joca.2015.05.023. Epub 2015 May 28.

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