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具有异质性校正功能的商业二次检查软件的验证与临床应用

Validation and clinical implementation of commercial secondary check software with heterogeneity corrections.

作者信息

Kuppusamy Vijayalakshmi, Nagarajan Vivekanandan, Murugan Lavanya

机构信息

Department of Medical Physics, Cancer Institute (WIA), Adyar, Chennai, India.

出版信息

Rep Pract Oncol Radiother. 2016 Sep-Oct;21(5):473-9. doi: 10.1016/j.rpor.2016.06.003. Epub 2016 Jul 16.

Abstract

AIM

To validate and implement PTW diamond secondary check software (SCS) in a routine clinical use.

BACKGROUND

The secondary independent monitor unit or dose calculation verifications have led to a significant increase in the workflow associated with QA treatments. Modelling, validation and commissioning are necessary steps thereby making it a useful tool for QA.

MATERIALS AND METHODS

PTW Diamond SCS is capable of calculating VMAT fields, based on modified Clarkson integration, accounting for multi-leaf collimators (MLC) transmission and measured collimator scatter factors. Validation for heterogeneity corrections is made using circular phantom with inserts of various density materials. 150 VMAT plans were compared using (i) plans calculated in homogeneous cylindrical phantom and (ii) VMAT plans calculated with heterogeneity corrections using electron density values for each organ.

RESULTS

Diamond SCS calculated dose for homogeneous cylindrical phantom resulted in average deviation of (0.1 ± 2.14%) with Eclipse TPS calculated dose and (-2.0 ± 1.66%) with absolute measured dose. PTW's OCTAVIUS-4D phantom with 729 ion chamber detector array measurements agreed well with Eclipse TPS calculated dose showing an average deviation of (-1.69 ± 1.56%). Diamond SCS dose calculations were performed with heterogeneity corrections for 124 VMAT plans with isocentre at a region above -350 HU. The overall MU variations between Diamond SCS and TPS Acuros-XB algorithms were within ±5%.

CONCLUSION

Hence, the Diamond SCS can be used as an additional tool along with phantom measurements for patient specific quality assurance of VMAT plans with heterogeneity corrections having isocentre at a region above -350 HU.

摘要

目的

在常规临床应用中验证并实施PTW钻石型二级检查软件(SCS)。

背景

二级独立监测单元或剂量计算验证导致与QA治疗相关的工作流程显著增加。建模、验证和调试是必要步骤,从而使其成为QA的有用工具。

材料与方法

PTW钻石型SCS能够基于改进的克拉克森积分计算容积调强弧形治疗(VMAT)射野,考虑多叶准直器(MLC)传输和测量的准直器散射因子。使用带有各种密度材料插入物的圆形模体对不均匀性校正进行验证。比较了150个VMAT计划,使用(i)在均匀圆柱形模体中计算的计划,以及(ii)使用每个器官的电子密度值进行不均匀性校正计算的VMAT计划。

结果

钻石型SCS计算的均匀圆柱形模体剂量与Eclipse治疗计划系统(TPS)计算的剂量平均偏差为(0.1±2.14%),与绝对测量剂量的平均偏差为(-2.0±1.66%)。带有729个电离室探测器阵列测量的PTW的OCTAVIUS-4D模体与Eclipse TPS计算的剂量吻合良好,平均偏差为(-1.69±1.56%)。对124个等中心位于-350 HU以上区域的VMAT计划进行了钻石型SCS剂量计算,并进行了不均匀性校正。钻石型SCS与TPS的Acuros-XB算法之间的总体跳数(MU)变化在±5%以内。

结论

因此,钻石型SCS可作为一种附加工具,与模体测量一起用于对等中心位于-350 HU以上区域且进行了不均匀性校正的VMAT计划进行患者特异性质量保证。

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