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炎症性肠病中的性别特异性问题。

Sex-Specific Issues in Inflammatory Bowel Disease.

作者信息

Rosenblatt Elizabeth, Kane Sunanda

机构信息

Dr Rosenblatt is a fellow at the University of Washington in Seattle, Washington. Dr Kane is a professor of medicine in the Department of Gastroenterology and Hepatology at the Mayo Clinic College of Medicine in Rochester, Minnesota.

出版信息

Gastroenterol Hepatol (N Y). 2015 Sep;11(9):592-601.

PMID:27482181
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4965619/
Abstract

Inflammatory bowel disease (IBD) affects approximately 1 in 500 people living in the United States and generally occurs with equal frequency in men and women. However, despite equal sex distribution of the disease, men and women face unique challenges that can significantly impact quality of life. As more is discovered regarding the pathogenesis, clinical manifestations, and treatment of IBD, physiologic and psychological differences between men and women with IBD have become increasingly apparent. It is important to understand these differences, as they have the potential to affect patient care and outcomes. This article will review sex-specific issues in IBD, such as impaired body image and sexuality, increased risk of cervical cancer, altered menstrual cycles, reduced fertility, and low bone mineral density.

摘要

炎症性肠病(IBD)影响着约每500名美国居民中的1人,并且在男性和女性中的发病率通常相同。然而,尽管该疾病在性别上分布均等,但男性和女性面临着可能显著影响生活质量的独特挑战。随着对IBD的发病机制、临床表现和治疗的了解越来越多,患有IBD的男性和女性之间的生理和心理差异日益明显。了解这些差异很重要,因为它们有可能影响患者护理和治疗结果。本文将综述IBD中与性别相关的问题,如身体形象和性功能受损、患宫颈癌风险增加、月经周期改变、生育能力下降以及骨矿物质密度低。

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本文引用的文献

1
Thrombosis in inflammatory bowel diseases: what's the link?炎症性肠病中的血栓形成:有何关联?
Thromb J. 2015 Apr 2;13:14. doi: 10.1186/s12959-015-0044-2. eCollection 2015.
2
Menstrual cycle, sex hormones in female inflammatory bowel disease patients with and without surgery.有手术史和无手术史的女性炎症性肠病患者的月经周期及性激素情况
J Dig Dis. 2015 May;16(5):245-55. doi: 10.1111/1751-2980.12247.
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Menopause.绝经。
Med Clin North Am. 2015 May;99(3):521-34. doi: 10.1016/j.mcna.2015.01.006.
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Endometriosis: a high-risk population for major chronic diseases?子宫内膜异位症:主要慢性疾病的高危人群?
Hum Reprod Update. 2015 Jul-Aug;21(4):500-16. doi: 10.1093/humupd/dmv013. Epub 2015 Mar 11.
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Crohn's disease.克罗恩病
BMJ. 2014 Nov 19;349:g6670. doi: 10.1136/bmj.g6670.
6
Women's health issues after ileal pouch surgery.回肠贮袋手术后的女性健康问题。
Inflamm Bowel Dis. 2014 Dec;20(12):2470-82. doi: 10.1097/MIB.0000000000000171.
7
Clinician's Guide to Prevention and Treatment of Osteoporosis.骨质疏松症防治临床指南
Osteoporos Int. 2014 Oct;25(10):2359-81. doi: 10.1007/s00198-014-2794-2. Epub 2014 Aug 15.
8
The impact of hormonal contraception on disease-related cyclical symptoms in women with inflammatory bowel diseases.激素避孕对炎症性肠病女性疾病相关周期性症状的影响。
Inflamm Bowel Dis. 2014 Oct;20(10):1729-33. doi: 10.1097/MIB.0000000000000134.
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Inflammatory bowel disease and cervical neoplasia: a population-based nationwide cohort study.炎症性肠病与宫颈癌:基于人群的全国性队列研究。
Clin Gastroenterol Hepatol. 2015 Apr;13(4):693-700.e1. doi: 10.1016/j.cgh.2014.07.036. Epub 2014 Jul 30.
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Increased risk of high grade cervical squamous intraepithelial lesions in systemic lupus erythematosus: A meta-analysis of the literature.系统性红斑狼疮患者发生高级别宫颈鳞状上皮内病变的风险增加:文献的荟萃分析。
Autoimmun Rev. 2014 Jul;13(7):730-5. doi: 10.1016/j.autrev.2014.03.001. Epub 2014 Mar 20.