Jang Shin Yi, Kim Sujin, Lee Chang Kwan, Cho Eun Jeong, Cho Soo Jin, Lee Sang-Chol
Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Department of Nursing, KC University, Seoul, Korea.
Korean Circ J. 2016 Jul;46(4):536-41. doi: 10.4070/kcj.2016.46.4.536. Epub 2016 Jul 21.
Left ventricular diastolic dysfunction is known to be a marker of myocardial damage, in particular myocardial fibrosis resulting from hypertension (HT). However, few studies have shown an association between the grade of diastolic dysfunction and blood pressure classification. We investigated the association between diastolic dysfunction and prehypertension (preHT) in apparently healthy adults who underwent routine health examinations.
The study sample included 4261 Koreans, 45 to 64 years of age with no previous history of HT, diabetes mellitus, malignancy, proven coronary artery disease, or valvular heart disease based on echocardiography, who underwent routine health examinations including echocardiography. The subjects were classified into three groups based on resting blood pressure: prehypertensive, hypertensive, and normotensive.
The prevalence of preHT in our study was 42.1%. After adjusting for age, gender, smoking status, alcohol consumption, fasting blood sugar, serum lipid profile, and body mass index, left ventricular diastolic dysfunction grades 1 and 2 were significantly more frequent in subjects with preHT (odds ratio [OR] 1.66 [95% confidence interval {CI} 1.40-1.96] and 1.37 [95% CI 0.95-1.97], respectively). When analyzed according to gender, the increased OR was especially notable in males.
Left ventricular diastolic dysfunction appears to be significantly associated with preHT in Korean middle-aged males.
左心室舒张功能障碍是心肌损伤的一个标志，尤其是高血压（HT）导致的心肌纤维化。然而，很少有研究表明舒张功能障碍的分级与血压分类之间存在关联。我们调查了接受常规健康检查的貌似健康的成年人中舒张功能障碍与高血压前期（preHT）之间的关联。
研究样本包括4261名45至64岁的韩国人，他们既往无HT、糖尿病、恶性肿瘤、经证实的冠状动脉疾病或基于超声心动图的瓣膜性心脏病病史，且接受了包括超声心动图在内的常规健康检查。根据静息血压将受试者分为三组：高血压前期、高血压和血压正常。
我们研究中高血压前期的患病率为42.1%。在调整年龄、性别、吸烟状况、饮酒量、空腹血糖、血脂谱和体重指数后，高血压前期受试者中1级和2级左心室舒张功能障碍的发生率显著更高（优势比[OR]分别为1.66[95%置信区间{CI}1.40 - 1.96]和1.37[95%CI 0.95 - 1.97]）。按性别分析时，OR的增加在男性中尤为显著。
在韩国中年男性中，左心室舒张功能障碍似乎与高血压前期显著相关。
